An assessment of the toxicity of polypropylene microplastics in human derived cells

被引：436

作者：

Hwang, Jangsun ^{[1
,2
]}

Choi, Daheui ^{[1
]}

Han, Seora ^{[1
]}

Choi, Jonghoon ^{[2
]}

Hong, Jinkee ^{[1
]}

机构：

[1] Yonsei Univ, Dept Chem & Biomol Engn, 50 Yonsei Ro, Seoul 03722, South Korea

[2] Chung Ang Univ, Sch Integrat Engn, 84,Heukseok Ro, Seoul 06974, South Korea

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 2019年 / 684卷

基金：

新加坡国家研究基金会;

关键词：

Plastic; Polypropylene microplastics; Immune response; Cytokines; Hypersensitivity; MARINE-ENVIRONMENT; FRESH-WATER; POLYSTYRENE MICROPLASTICS; INFLAMMATORY CYTOKINES; MOLECULAR-WEIGHT; FLAME-RETARDANT; PLASTIC DEBRIS; TEXTILE FIBERS; MAST-CELLS; PARTICLES;

D O I：

10.1016/j.scitotenv.2019.05.071

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Environmental pollution caused by plastic waste is a growing global problem. Discarded plastic products and debris (microplastic particles) in the oceans detrimentally affect marine ecosystems and may impact human. Humans are exposed to plastic debris via the consumption of seafood and drinking water, contact with food packaging, or inhalation of particles. The accumulation of microplastic particles in humans has potential health risks such as cytotoxicity, hypersensitivity, unwanted immune response, and acute response like hemolysis. We investigated the cellular responses of secondary polypropylene microplastics (PP particles) of approximately similar to 20 mu m and 25-200 mu m in different condition and size to normal cells, immune cells, blood cells, and murine immune cells by cytokine analysis, ROS assay, polarization assay and proliferation assay. We found that PP particles showed low cytotoxicity effect in size and concentration manner, however, a high concentration, small sized, DMSO method of PP particles stimulated the immune system and enhanced potential hypersensitivity to PP particles via an increase in the levels of cytokines and histamines in PBMCs, Raw 264.7 and HMC-1 cells. (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：657 / 669

页数：13

共 113 条

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