'LungGENS': a web-based tool for mapping single-cell gene expression in the developing lung

被引:102
作者
Du, Yina [1 ,2 ]
Guo, Minzhe [1 ,2 ,3 ]
Whitsett, Jeffrey A. [1 ,2 ]
Xu, Yan [1 ,2 ,4 ]
机构
[1] Cincinnati Childrens Hosp Med Ctr, Dept Perinatal & Pulm Biol, Perinatal Inst, Cincinnati, OH 45229 USA
[2] Cincinnati Childrens Hosp Med Ctr, Sect Neonatol, Cincinnati, OH 45229 USA
[3] Univ Cincinnati, Dept Elect Engn & Comp Syst, Cincinnati, OH USA
[4] Cincinnati Childrens Hosp Med Ctr, Div Biomed Informat, Cincinnati, OH 45229 USA
关键词
MOUSE;
D O I
10.1136/thoraxjnl-2015-207035
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
We developed LungGENS (Lung Gene Expression iN Single-cell), a web-based bioinformatics resource for querying single-cell gene expression databases by entering a gene symbol or a list of genes or selecting a cell type of their interest. Gene query provides quantitative RNA expression of the gene of interest in each lung cell type. Cell type query returns associated selective gene signatures and genes encoding cell surface markers and transcription factors in interactive heatmap and tables. LungGENS will be broadly applicable in respiratory research, providing a cell-specific RNA expression resource at single-cell resolution. LungGENS is freely available for non-commercial use at https://research.cchmc.org/pbge/lunggens/default.html.
引用
收藏
页码:1092 / 1094
页数:3
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