Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients

被引:28
作者
Dvojkovic, Anja [1 ]
Perkovic, Matea Nikolac [2 ]
Sagud, Marina [3 ,4 ]
Erjavec, Gordana Nedic [2 ]
Peles, Alma Mihaljevic [3 ,4 ]
Strac, Dubravka Svob [2 ]
Cusa, Bjanka Vuksan [3 ,4 ]
Tudor, Lucija [2 ]
Kusevic, Zorana [3 ,4 ]
Konjevod, Marcela [2 ]
Zivkovic, Maja [4 ]
Jevtovic, Sasa [3 ,4 ]
Pivac, Nela [2 ]
机构
[1] Univ Psychiat Hosp Vrapce, Bolnicka Cesta 32, HR-10090 Zagreb, Croatia
[2] Rudjer Boskovic Inst, Bijenicka Cesta 54, HR-10000 Zagreb, Croatia
[3] Univ Zagreb, Sch Med, Salata 3, HR-10000 Zagreb, Croatia
[4] Univ Hosp Ctr Zagreb, Dept Psychiat & Psychol Med, Zagreb, Croatia
关键词
Depression; Escitalopram; Plasma BDNF; Platelet serotonin; Patients; Vortioxetine; PERIPHERAL BIOCHEMICAL MARKERS; NEUROTROPHIC FACTOR LEVELS; MAJOR DEPRESSION; ANTIDEPRESSANT VORTIOXETINE; BLOOD-BRAIN; SHORT-TERM; SERUM; PAROXETINE; DISORDER; BIOMARKER;
D O I
10.1016/j.pnpbp.2020.110016
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Escitalopram and vortioxetine are efficacious antidepressants. They directly target serotonin (5-HT) system, but vortioxetine mechanism of action is distinct from the one of selective serotonin reuptake inhibitors (SSRIs). Treatment with SSRIs decrease platelet 5-HT concentration and increase peripheral brain-derived neurotrophic factor (BDNF) levels. Since vortioxetine has a multimodal mechanism of action, it is expected to have a greater effect on circulatory BDNF concentration, compared to conventional antidepressants. This longitudinal study aimed to explore and compare the effects of 4-weeks of treatment with vortioxetine and escitalopram on plasma BDNF and platelet 5-HT concentration in patients with major depressive disorder (MDD). The results revealed that vortioxetine significantly increased plasma BDNF concentration (p = .018) and significantly decreased platelet 5-HT concentration (p < .001). Treatment with escitalopram significantly decreased platelet 5-HT concentration (p < .001), but it did not affect plasma BDNF concentration (p = .379). Response to vortioxetine was not predicted by baseline plasma BDNF or platelet 5-HT concentration, but response to escitalopram was predicted by baseline platelet 5-HT concentration. These effects might be due to vortioxetine unique mechanism of action, but the clinical implications are unclear. It remains to be determined whether this finding extends during long-term vortioxetine treatment, and which, if any, clinical effects emerge from BDNF increase.
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页数:11
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