Regulatory feedback loop between T3 and microRNAs in renal cancer

被引：18

作者：

Boguslawska, J. ^{[1
]}

Piekielko-Witkowska, A. ^{[1
]}

Wojcicka, A. ^{[1
]}

Kedzierska, H. ^{[1
]}

Poplawski, P. ^{[1
]}

Nauman, A. ^{[1
]}

机构：

[1] Med Ctr Postgrad Educ, Dept Biochem & Mol Biol, PL-01813 Warsaw, Poland

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2014年 / 384卷 / 1-2期

关键词：

Type 1 5'-iodothyronine deiodinase; MicroRNA; Renal cancer; 3,5,3' Triiodothyronine; MiR-224; MiR-452; THYROID-HORMONE; GENE-EXPRESSION; MOLECULAR CLASSIFICATION; KIDNEY;

D O I：

10.1016/j.mce.2014.01.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

microRNAs, short non-coding RNAs, influence key physiological processes, including hormonal regulation, by affecting the expression of genes. In this study we hypothesised that the expression of microRNAs targeting thyroid hormone pathway genes may be in turn regulated by thyroid hormone signalling. It is known that the expression of DIO1, a gene contributing to triiodothyronine (T3) signalling, is regulated by miR-224. Thus, we analysed mutual regulation between triiodothyronine pathway and miR-224/miR-452/GABRE cluster. Firstly, we found that miR-452 directly regulates the expression of thyroid hormone receptor TR beta 1 in renal cancer cells. In turn, the expression of miR-224/452/GABRE cluster and other microRNAs targeting TR beta 1 was influenced by T3 treatment and/or TR silencing. miR-452 expression correlated with intracellular T3 concentrations in renal tumours. In conclusion, we propose a new mechanism of feedback regulation, by which in renal cancer microRNAs regulate the expression of T3 pathway genes, while T3 in turn regulates expression of microRNAs. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：61 / 70

页数：10

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