Mechanism and physiological significance of programmed replication termination

被引:17
作者
Bastia, Deepak [1 ]
Zaman, Shamsu [1 ]
机构
[1] Med Univ S Carolina, Dept Biochem & Mol Biol, Charleston, SC 29425 USA
关键词
Replication termination; Terminator protein; Crystal structure; Recombination; Replicative aging; Gene silencing; RIBOSOMAL-RNA GENES; BLOCK PROTEIN FOB1; ESCHERICHIA-COLI; DNA-REPLICATION; BACILLUS-SUBTILIS; FORK-ARREST; TERMINUS REGION; SCHIZOSACCHAROMYCES-POMBE; TOPOISOMERASE-IV; BINDING PROTEIN;
D O I
10.1016/j.semcdb.2014.04.030
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Replication forks in both prokaryotic and eukaryotic systems pause at random sites due to depletion of dNTP pools, DNA damage, tight binding nonhistone proteins or unusual DNA sequences and/or structures, in a mostly non-polar fashion. However, there is also physiologically programmed replication termination at sequence-specific authentic replication termini. Here, the structure and functions of programined replication termini, their mechanism of action and their diverse physiological functions in prokaryotes and eukaryotes have been reviewed. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码:165 / 173
页数:9
相关论文
共 97 条
[31]  
Henderson TA, 2001, MOL GENET GENOMICS, V265, P941
[32]  
HIDAKA M, 1989, J BIOL CHEM, V264, P21031
[33]   TUS, THE TRANS-ACTING GENE REQUIRED FOR TERMINATION OF DNA-REPLICATION IN ESCHERICHIA-COLI, ENCODES A DNA-BINDING PROTEIN [J].
HILL, TM ;
TECKLENBURG, ML ;
PELLETIER, AJ ;
KUEMPEL, PL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (05) :1593-1597
[34]   IDENTIFICATION OF THE DNA-SEQUENCE FROM THE ESCHERICHIA-COLI TERMINUS REGION THAT HALTS REPLICATION FORKS [J].
HILL, TM ;
PELLETIER, AJ ;
TECKLENBURG, ML ;
KUEMPEL, PL .
CELL, 1988, 55 (03) :459-466
[35]  
HILL TM, 1992, ANNU REV MICROBIOL, V46, P603, DOI 10.1146/annurev.micro.46.1.603
[36]   Lsd1 and Lsd2 Control Programmed Replication Fork Pauses and Imprinting in Fission Yeast [J].
Holmes, Allyson ;
Roseaulin, Laura ;
Schurra, Catherine ;
Waxin, Herve ;
Lambert, Sarah ;
Zaratiegui, Mikel ;
Martienssen, Robert A. ;
Arcangioli, Benoit .
CELL REPORTS, 2012, 2 (06) :1513-1520
[37]   CORE SEQUENCE OF 2 SEPARABLE TERMINUS SITES OF THE R6K-PLASMID THAT EXHIBIT POLAR INHIBITION OF REPLICATION IS A 20-BP INVERTED REPEAT [J].
HORIUCHI, T ;
HIDAKA, M .
CELL, 1988, 54 (04) :515-523
[38]   Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing [J].
Huang, J ;
Moazed, D .
GENES & DEVELOPMENT, 2003, 17 (17) :2162-2176
[39]   Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer [J].
Huang, Julie ;
Brito, Ilana L. ;
Villen, Judit ;
Gygi, Steven P. ;
Amon, Angelika ;
Moazed, Danesh .
GENES & DEVELOPMENT, 2006, 20 (20) :2887-2901
[40]   Schizosaccharomyces pombe Rtf2 mediates site-specific replication termination by inhibiting replication restart [J].
Inagawa, Takabumi ;
Yamada-Inagawa, Tomoko ;
Eydmann, Trevor ;
Mian, I. Saira ;
Wang, Teresa S. ;
Dalgaard, Jacob Z. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (19) :7927-7932