Mechanism and physiological significance of programmed replication termination

被引：17
作者：
Bastia, Deepak [1 ]
Zaman, Shamsu [1 ]
机构：
[1] Med Univ S Carolina, Dept Biochem & Mol Biol, Charleston, SC 29425 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2014年 / 30卷
关键词：
Replication termination; Terminator protein; Crystal structure; Recombination; Replicative aging; Gene silencing; RIBOSOMAL-RNA GENES; BLOCK PROTEIN FOB1; ESCHERICHIA-COLI; DNA-REPLICATION; BACILLUS-SUBTILIS; FORK-ARREST; TERMINUS REGION; SCHIZOSACCHAROMYCES-POMBE; TOPOISOMERASE-IV; BINDING PROTEIN;
D O I：
10.1016/j.semcdb.2014.04.030
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Replication forks in both prokaryotic and eukaryotic systems pause at random sites due to depletion of dNTP pools, DNA damage, tight binding nonhistone proteins or unusual DNA sequences and/or structures, in a mostly non-polar fashion. However, there is also physiologically programmed replication termination at sequence-specific authentic replication termini. Here, the structure and functions of programined replication termini, their mechanism of action and their diverse physiological functions in prokaryotes and eukaryotes have been reviewed. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：165 / 173
页数：9
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