Rhodium(III)-Catalyzed ortho Alkenylation of N-Phenoxyacetamides with N-Tosylhydrazones or Diazoesters through C-H Activation

被引：219

作者：

Hu, Fangdong ^{[1
,2
,3
]}

Xia, Ying ^{[1
,2
]}

Ye, Fei ^{[1
,2
]}

Liu, Zhenxing ^{[1
,2
]}

Ma, Chen ^{[1
,2
,3
]}

Zhang, Yan ^{[1
,2
]}

Wang, Jianbo ^{[1
,2
]}

机构：

[1] Peking Univ, Coll Chem, BNLMS, Beijing 100871, Peoples R China

[2] Peking Univ, Coll Chem, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Beijing 100871, Peoples R China

[3] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 05期

基金：

中国国家自然科学基金;

关键词：

C-H activation; diazo compounds; homogeneous catalysis; metal-carbene complexes; migratory insertion; DIAZO-COMPOUNDS; BOND FORMATION; DIRHODIUM(II) CARBOXYLATES; INSERTION REACTIONS; DIRECTING GROUP; ALKYNES; FUNCTIONALIZATION; CONSTRUCTION; REACTIVITIES; ISOCYANATES;

D O I：

10.1002/anie.201309650

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A coupling reaction of N-phenoxyacetamides with N-tosylhydrazones or diazoesters through Rh-III-catalyzed C-H activation is reported. In this reaction, ortho-alkenyl phenols were obtained in good yields and with excellent regio- and stereoselectivity. Rh-carbene migratory insertion is proposed as the key step in the reaction mechanism.

引用

页码：1364 / 1367

页数：4

共 51 条

[1]

[Anonymous], 2012, ANGEW CHE, DOI DOI 10.1002/ANGE.201201273

[2]

[Anonymous], 2012, ANGEW CHEM INT ED, V51, P7318

[3]

[Anonymous], 2013, ANGEW CHEM INT ED, V52, P12426

[4]

[Anonymous], 2013, ANGEW CHEM INT ED, V52, P6033