Emergence of G186D Mutation in the Presence of R292K Mutation in an Immunocompromised Child Infected with Influenza A/H3N2 Virus, Treated with Oseltamivir

被引：3

作者：

Lee, Hong Kai ^{[1
,2
]}

Tang, Julian Wei-Tze ^{[3
,4
]}

Loh, Tze Ping ^{[2
]}

Kong, Debra Han-Lin ^{[2
]}

Lau, Yew-Weng ^{[5
]}

Yap, Hui Kim ^{[5
]}

Koay, Evelyn Siew-Chuan ^{[1
,2
]}

机构：

[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pathol, Singapore 117548, Singapore

[2] Natl Univ Hlth Syst, Natl Univ Hosp, Dept Lab Med, Singapore, Singapore

[3] Univ Alberta Hosp, Alberta Prov Lab Publ Hlth, Edmonton, AB T6G 2B7, Canada

[4] Univ Alberta, Dept Med Microbiol & Immunol, Edmonton, AB, Canada

[5] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pediat, Singapore 117548, Singapore

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2014年 / 52卷 / 05期

基金：

英国医学研究理事会;

关键词：

HEMAGGLUTININ; NEURAMINIDASE; RESISTANCE; INHIBITORS; GENE;

D O I：

10.1128/JCM.00538-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An immunocompromised child with influenza A/H3N2 virus infection, treated with oseltamivir from day 1, had nasal swabs taken on days 1, 4, 7, and 10 of the illness. Pyrosequencing showed increasing proportions of viruses with R292K (neuraminidase gene) and G186D (hemagglutinin gene) mutations, resulting in a viral load rebound by day 10.

引用

页码：1749 / 1750

页数：2

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