Dibenzofuran and pyranone metabolites from Hypericum revolutum ssp revolutum and Hypericum choisianum

被引：27

作者：

Shiu, Winnie Ka Po ^{[1
]}

Gibbons, Simon ^{[1
]}

机构：

[1] Univ London, Ctr Pharmacognosy & Phytotherapy, Sch Pharm, London WC1N 1AX, England

来源：

PHYTOCHEMISTRY | 2009年 / 70卷 / 03期

基金：

英国工程与自然科学研究理事会;

关键词：

Hypericum revolutum; Hypericum choisianum; Guttiferae; Dibenzofuran; Pyranone; Pyran-2-one; Antibacterial; MRSA; Staphylococcus aureus; MDR; IN-VITRO ACTIVITY; STAPHYLOCOCCUS-AUREUS; PHYTOALEXINS; DETERMINANT; RESISTANCE; GUTTIFERAE; SAPWOOD;

D O I：

10.1016/j.phytochem.2008.12.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In a project to isolate and characterise anti-staphylococcal compounds from members of the genus Hypericum, a dibenzofuran and a pyranone were isolated from the dichloromethane and hexane extracts of Hypericum revolutum ssp. revolutum Vahl (Guttiferae) and Hypericum choisianum Wall. ex. N. Robson (Guttiferae), respectively. The structures of these compounds were elucidated by 1- and 2D-NMR spectroscopy and mass spectrometry as 3-hydroxy-1,4,7-trimethoxydibenzofuran (1) and 4-(3-0-3 '')-3 ''-methylbutenyl-6-phenyl-pyran-2-one (2). The metabolites were evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus. Compound I exhibited a minimum inhibitory concentration (MIC) of 256 mu g/ml, whereas compound 2 was inactive at a concentration of 512 mu g/ml. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：403 / 406

页数：4

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