Microfluidic Platform for the Continuous Production and Characterization of Multilamellar Vesicles: A Synchrotron Small-Angle X-ray Scattering (SAXS) Study

被引：37

作者：

Ghazal, Aghiad ^{[1
,2
]}

Gontsarik, Mark ^{[2
]}

Kutter, Jorg P. ^{[2
]}

Lafleur, Josiane P. ^{[2
]}

Ahmadvand, Davoud ^{[3
]}

Labrador, Ana ^{[4
]}

Salentinig, Stefan ^{[5
]}

Yaghmur, Anan ^{[2
]}

机构：

[1] Univ Copenhagen, Niels Bohr Inst, Univ Pk 5, DK-2100 Copenhagen O, Denmark

[2] Univ Copenhagen, Fac Hlth & Med Sci, Dept Pharm, Univ Pk 2, DK-2100 Copenhagen O, Denmark

[3] Iran Univ Med Sci, Shahid Hemmat Highway, Tehran, Iran

[4] Lund Univ, MAX IV Lab, S-22362 Lund, Sweden

[5] Empa Swiss Fed Labs Mat Sci & Technol, Lab Biointerfaces Empa, Lerchenfeldstr 5, CH-9014 St Gallen, Switzerland

来源：

JOURNAL OF PHYSICAL CHEMISTRY LETTERS | 2017年 / 8卷 / 01期

关键词：

LIPOSOMES; NANOPARTICLES; MONODISPERSE; PHYTANTRIOL; LAMELLAR; SYSTEMS; PHASES; ENCAPSULATION; MESOPHASES; DEVICES;

D O I：

10.1021/acs.jpclett.6b02468

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A microfluidic platform combined with synchrotron small-angle X-ray scattering (SAXS) was used for monitoring the continuous production of multilamellar vesicles (MLVs). Their production was fast and started to evolve within less than 0.43 s of contact between the lipids and the aqueous phase. To obtain nanoparticles with a narrow size distribution, it was important to use a modified hydrodynamic flow focusing (HFF) microfluidic device with narrower microchannels than those normally used for SAXS experiments. Monodispersed MLVs as small as 160 nm in size, with a polydispersity index (PDI) of approximately 0.15 were achieved. The nanoparticles produced were smaller and had a narrower size distribution than those obtained via conventional bulk mixing methods. This microfluidic platform therefore has a great potential for the continuous production of monodispersed NPs.

引用

页码：73 / 79

页数：7

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