Natural Drugs as a Treatment Strategy for Cardiovascular Disease through the Regulation of Oxidative Stress

被引：71

作者：

Chang, Xing ^{[1
,2
]}

Zhang, Tian ^{[3
]}

Zhang, Wenjin ^{[1
]}

Zhao, Zhenyu ^{[1
]}

Sun, Jiahui ^{[1
]}

机构：

[1] China Acad Chinese Med Sci, State Key Lab Breeding Base Dao Di Herbs, Natl Resource Ctr Chinese Mat Med, Beijing 100700, Peoples R China

[2] Chinese Acad Tradit Chinese Med, Guanganmen Hosp, Beijing 100053, Peoples R China

[3] Shandong Univ Tradit Chinese Med, Jinan 250355, Shandong, Peoples R China

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2020年 / 2020卷

关键词：

CORONARY-HEART-DISEASE; ISCHEMIA-REPERFUSION INJURY; GASTRODIA-ELATA-BLUME; HYDROXY SAFFLOWER YELLOW; ASTRAGALOSIDE-IV; MYOCARDIAL-ISCHEMIA; MITOCHONDRIAL DYSFUNCTION; ENDOTHELIAL DYSFUNCTION; SOYBEAN ISOFLAVONE; DIABETES-MELLITUS;

D O I：

10.1155/2020/5430407

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Oxidative stress (OS) refers to the physiological imbalance between oxidative and antioxidative processes leading to increased oxidation, which then results in the inflammatory infiltration of neutrophils, increased protease secretion, and the production of a large number of oxidative intermediates. Oxidative stress is considered an important factor in the pathogenesis of cardiovascular disease (CVD). At present, active components of Chinese herbal medicines (CHMs) have been widely used for the treatment of CVD, including coronary heart disease and hypertension. Since the discovery of artemisinin for the treatment of malaria by Nobel laureate Youyou Tu, the therapeutic effects of active components of CHM on various diseases have been widely investigated by the medical community. It has been found that various active CHM components can regulate oxidative stress and the circulatory system, including ginsenoside, astragaloside, and resveratrol. This paper reviews advances in the use of active CHM components that modulate oxidative stress, suggesting potential drugs for the treatment of various CVDs.

引用

页数：20

共 214 条

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