共 49 条
Herpes simplex virus RNAi and neprilysin gene transfer vectors reduce accumulation of Alzheimer's disease-related amyloid-β peptide in vivo
被引:83
作者:

Hong, C-S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA

Goins, W. F.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA

Goss, J. R.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA

Burton, E. A.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA

Glorioso, J. C.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA
机构:
[1] Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA
[2] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA
关键词:
herpes simplex virus;
Alzheimer's disease;
amyloid-beta protein;
siRNA;
neprilysin;
lentivirus;
D O I:
10.1038/sj.gt.3302719
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Accumulation of insoluble aggregates of amyloid-beta peptide ( A beta), a cleavage product of amyloid precursor protein ( APP), is thought to be central to the pathogenesis of Alzheimer's disease ( AD). Consequently, downregulation of APP, or enhanced clearance of A beta, represent possible therapeutic strategies for AD. We generated replication-defective herpes simplex virus ( HSV) vectors that inhibit A beta accumulation, both in vitro and in vivo. In cell culture, HSV vectors expressing either ( i) short hairpin RNA directed to the APP transcript ( HSV-APP/shRNA), or ( ii) neprilysin, an endopeptidase that degrades A beta ( HSV-neprilysin), substantially inhibited accumulation of A beta. To determine whether these vectors showed similar activity in vivo, we developed a novel mouse model, in which overexpression of a mutant form of APP in the hippocampus, using a lentiviral vector ( LV-APP(Sw)), resulted in rapid A beta accumulation. Co-inoculation of LV-APP(Sw) with each of the HSV vectors showed that either HSV-APP/shRNA or HSV-neprilysin inhibited A beta accumulation in this model, whereas an HSV control vector did not. These studies demonstrate the utility of HSV vectors for reducing A beta accumulation in the brain, thus providing useful tools to clarify the role of A beta in AD that may facilitate the development of novel therapies for this important disease.
引用
收藏
页码:1068 / 1079
页数:12
相关论文
共 49 条
[11]
A NOVEL LATENCY-ACTIVE PROMOTER IS CONTAINED WITHIN THE HERPES-SIMPLEX VIRUS TYPE-1 U-L FLANKING REPEATS
[J].
GOINS, WF
;
STERNBERG, LR
;
CROEN, KD
;
KRAUSE, PR
;
HENDRICKS, RL
;
FINK, DJ
;
STRAUS, SE
;
LEVINE, M
;
GLORIOSO, JC
.
JOURNAL OF VIROLOGY,
1994, 68 (04)
:2239-2252

GOINS, WF
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH,SCH MED,DEPT MOLEC GENET & BIOCHEM,PITTSBURGH,PA 15261

STERNBERG, LR
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH,SCH MED,DEPT MOLEC GENET & BIOCHEM,PITTSBURGH,PA 15261

CROEN, KD
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH,SCH MED,DEPT MOLEC GENET & BIOCHEM,PITTSBURGH,PA 15261

KRAUSE, PR
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH,SCH MED,DEPT MOLEC GENET & BIOCHEM,PITTSBURGH,PA 15261

HENDRICKS, RL
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH,SCH MED,DEPT MOLEC GENET & BIOCHEM,PITTSBURGH,PA 15261

FINK, DJ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH,SCH MED,DEPT MOLEC GENET & BIOCHEM,PITTSBURGH,PA 15261

STRAUS, SE
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH,SCH MED,DEPT MOLEC GENET & BIOCHEM,PITTSBURGH,PA 15261

LEVINE, M
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH,SCH MED,DEPT MOLEC GENET & BIOCHEM,PITTSBURGH,PA 15261

GLORIOSO, JC
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH,SCH MED,DEPT MOLEC GENET & BIOCHEM,PITTSBURGH,PA 15261
[12]
Herpes simplex virus type 1 vector-mediated expression of nerve growth factor protects dorsal root ganglion neurons from peroxide toxicity
[J].
Goins, WF
;
Lee, KA
;
Cavalcoli, JD
;
O'Malley, ME
;
DeKosky, ST
;
Fink, DJ
;
Glorioso, JC
.
JOURNAL OF VIROLOGY,
1999, 73 (01)
:519-532

Goins, WF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA

Lee, KA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA

Cavalcoli, JD
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA

O'Malley, ME
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA

DeKosky, ST
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA

Fink, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA

Glorioso, JC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15261 USA
[13]
Herpes simplex-mediated gene transfer of nerve growth factor protects against peripheral neuropathy in streptozotocin-induced diabetes in the mouse
[J].
Goss, JR
;
Goins, WF
;
Lacomis, D
;
Mata, M
;
Glorioso, JC
;
Fink, DJ
.
DIABETES,
2002, 51 (07)
:2227-2232

Goss, JR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

Goins, WF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

Lacomis, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

Mata, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

Glorioso, JC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

Fink, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA
[14]
Antinociceptive effect of a genomic herpes simplex virus-based vector expressing human proenkephalin in rat dorsal roof ganglion
[J].
Goss, JR
;
Mata, M
;
Goins, WF
;
Wu, HH
;
Glorioso, JC
;
Fink, DJ
.
GENE THERAPY,
2001, 8 (07)
:551-556

Goss, JR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

Mata, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

Goins, WF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

Wu, HH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

Glorioso, JC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

Fink, DJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA
[15]
Polymorphisms in neprilysin gene affect the risk of Alzheimer's disease in Finnish patients
[J].
Helisalmi, S
;
Hiltunen, M
;
Vepsäläinen, S
;
Iivonen, S
;
Mannermaa, A
;
Lehtovirta, M
;
Koivisto, AM
;
Alafuzoff, I
;
Soininen, H
.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY,
2004, 75 (12)
:1746-1748

Helisalmi, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Kuopio, Dept Neurol & Neurosci, Brain Res Unit, Clin Res Ctr Mediteknia, FIN-70211 Kuopio, Finland

Hiltunen, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Kuopio, Dept Neurol & Neurosci, Brain Res Unit, Clin Res Ctr Mediteknia, FIN-70211 Kuopio, Finland

Vepsäläinen, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Kuopio, Dept Neurol & Neurosci, Brain Res Unit, Clin Res Ctr Mediteknia, FIN-70211 Kuopio, Finland

Iivonen, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Kuopio, Dept Neurol & Neurosci, Brain Res Unit, Clin Res Ctr Mediteknia, FIN-70211 Kuopio, Finland

Mannermaa, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Kuopio, Dept Neurol & Neurosci, Brain Res Unit, Clin Res Ctr Mediteknia, FIN-70211 Kuopio, Finland

Lehtovirta, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Kuopio, Dept Neurol & Neurosci, Brain Res Unit, Clin Res Ctr Mediteknia, FIN-70211 Kuopio, Finland

Koivisto, AM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Kuopio, Dept Neurol & Neurosci, Brain Res Unit, Clin Res Ctr Mediteknia, FIN-70211 Kuopio, Finland

Alafuzoff, I
论文数: 0 引用数: 0
h-index: 0
机构: Univ Kuopio, Dept Neurol & Neurosci, Brain Res Unit, Clin Res Ctr Mediteknia, FIN-70211 Kuopio, Finland

Soininen, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Kuopio, Dept Neurol & Neurosci, Brain Res Unit, Clin Res Ctr Mediteknia, FIN-70211 Kuopio, Finland
[16]
Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-β peptide in mouse brain
[J].
Iwata, N
;
Mizukami, H
;
Shirotani, K
;
Takaki, Y
;
Muramatsu, S
;
Lu, B
;
Gerard, NP
;
Gerard, C
;
Ozawa, K
;
Saido, TC
.
JOURNAL OF NEUROSCIENCE,
2004, 24 (04)
:991-998

Iwata, N
论文数: 0 引用数: 0
h-index: 0
机构:
RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Mizukami, H
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Shirotani, K
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Takaki, Y
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Muramatsu, S
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Lu, B
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Gerard, NP
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Gerard, C
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Ozawa, K
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Saido, TC
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan
[17]
Identification of the major Aβ1-42-degrading catabolic pathway in brain parenchyma:: Suppression leads to biochemical and pathological deposition
[J].
Iwata, N
;
Tsubuki, S
;
Takaki, Y
;
Watanabe, K
;
Sekiguchi, M
;
Hosoki, E
;
Kawashima-Morishima, M
;
Lee, HJ
;
Hama, E
;
Sekine-Aizawa, Y
;
Saido, TC
.
NATURE MEDICINE,
2000, 6 (02)
:143-150

Iwata, N
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Tsubuki, S
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Takaki, Y
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Watanabe, K
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Sekiguchi, M
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Hosoki, E
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Kawashima-Morishima, M
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Lee, HJ
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Hama, E
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Sekine-Aizawa, Y
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Saido, TC
论文数: 0 引用数: 0
h-index: 0
机构:
RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan
[18]
Metabolic regulation of brain Aβ by neprilysin
[J].
Iwata, N
;
Tsubuki, S
;
Takaki, Y
;
Shirotani, K
;
Lu, B
;
Gerard, NP
;
Gerard, C
;
Hama, E
;
Lee, HJ
;
Saido, TC
.
SCIENCE,
2001, 292 (5521)
:1550-1552

Iwata, N
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Tsubuki, S
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Takaki, Y
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Shirotani, K
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Lu, B
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Gerard, NP
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Gerard, C
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Hama, E
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Lee, HJ
论文数: 0 引用数: 0
h-index: 0
机构: RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan

Saido, TC
论文数: 0 引用数: 0
h-index: 0
机构:
RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan RIKEN, Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan
[19]
Intracellular amyloid-β1-42, but not extracellular soluble amyloid-β peptides, induces neuronal apoptosis
[J].
Kienlen-Campard, P
;
Miolet, S
;
Tasiaux, B
;
Octave, JN
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2002, 277 (18)
:15666-15670

Kienlen-Campard, P
论文数: 0 引用数: 0
h-index: 0
机构:
Catholic Univ Louvain, FARL UCL 54 10, B-1200 Brussels, Belgium Catholic Univ Louvain, FARL UCL 54 10, B-1200 Brussels, Belgium

Miolet, S
论文数: 0 引用数: 0
h-index: 0
机构:
Catholic Univ Louvain, FARL UCL 54 10, B-1200 Brussels, Belgium Catholic Univ Louvain, FARL UCL 54 10, B-1200 Brussels, Belgium

Tasiaux, B
论文数: 0 引用数: 0
h-index: 0
机构:
Catholic Univ Louvain, FARL UCL 54 10, B-1200 Brussels, Belgium Catholic Univ Louvain, FARL UCL 54 10, B-1200 Brussels, Belgium

Octave, JN
论文数: 0 引用数: 0
h-index: 0
机构:
Catholic Univ Louvain, FARL UCL 54 10, B-1200 Brussels, Belgium Catholic Univ Louvain, FARL UCL 54 10, B-1200 Brussels, Belgium
[20]
Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors
[J].
Kirik, D
;
Björklund, A
.
TRENDS IN NEUROSCIENCES,
2003, 26 (07)
:386-392

Kirik, D
论文数: 0 引用数: 0
h-index: 0
机构:
Lund Univ, Wallenberg Neurosci Ctr, Dept Physiol Sci, S-22184 Lund, Sweden Lund Univ, Wallenberg Neurosci Ctr, Dept Physiol Sci, S-22184 Lund, Sweden

Björklund, A
论文数: 0 引用数: 0
h-index: 0
机构:
Lund Univ, Wallenberg Neurosci Ctr, Dept Physiol Sci, S-22184 Lund, Sweden Lund Univ, Wallenberg Neurosci Ctr, Dept Physiol Sci, S-22184 Lund, Sweden