Acoustic tweezers: patterning cells and microparticles using standing surface acoustic waves (SSAW)

被引:594
作者
Shi, Jinjie [1 ]
Ahmed, Daniel [1 ]
Mao, Xiaole [1 ,2 ]
Lin, Sz-Chin Steven [1 ]
Lawit, Aitan [1 ]
Huang, Tony Jun [1 ,2 ]
机构
[1] Penn State Univ, Dept Engn Sci & Mech, University Pk, PA 16802 USA
[2] Penn State Univ, Dept Bioengn, University Pk, PA 16802 USA
基金
美国国家科学基金会;
关键词
MICROMETER-SIZED PARTICLES; MICROFLUIDIC CHANNEL; SINGLE CELLS; MANIPULATION; CHIP; MICROARRAYS; TECHNOLOGY; PARALLEL; DOCKING; DEVICE;
D O I
10.1039/b910595f
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Here we present an active patterning technique named "acoustic tweezers'' that utilizes standing surface acoustic wave (SSAW) to manipulate and pattern cells and microparticles. This technique is capable of patterning cells and microparticles regardless of shape, size, charge or polarity. Its power intensity, approximately 5 X 10(5) times lower than that of optical tweezers, compares favorably with those of other active patterning methods. Flow cytometry studies have revealed it to be non-invasive. The aforementioned advantages, along with this technique's simple design and ability to be miniaturized, render the "acoustic tweezers'' technique a promising tool for various applications in biology, chemistry, engineering, and materials science.
引用
收藏
页码:2890 / 2895
页数:6
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