Memory CD8+ T cell responses to cancer

被引：131

作者：

Han, Jichang ^{[1
]}

Khatwani, Nikhil ^{[1
]}

Searles, Tyler G. ^{[2
]}

Turk, Mary Jo ^{[1
,2
]}

Angeles, Christina, V ^{[3
,4
]}

机构：

[1] Geisel Sch Med Dartmouth, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

[2] Geisel Sch Med Dartmouth, Norris Cotton Canc Ctr, Lebanon, NH 03756 USA

[3] Univ Michigan, Sch Med, Dept Surg, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Comprehens Canc Ctr, Ann Arbor, MI 48109 USA

来源：

SEMINARS IN IMMUNOLOGY | 2020年 / 49卷

关键词：

Resident memory (T-RM); Stem cell memory (T-SCM); Effector memory (T-EM); Central memory (T-CM); Tumor immunity; Exhaustion; TISSUE-RESIDENT MEMORY; TUMOR-INFILTRATING LYMPHOCYTES; STEM-CELLS; CUTTING EDGE; IN-VIVO; NONLYMPHOID TISSUES; PROGNOSTIC-FACTOR; IMMUNE-RESPONSE; EFFECTOR; DIFFERENTIATION;

D O I：

10.1016/j.smim.2020.101435

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Long-lived memory CD8(+) T cells play important roles in tumor immunity. Studies over the past two decades have identified four subsets of memory CD8(+) T cells - central, effector, stem-like, and tissue resident memory - that either circulate through blood, lymphoid and peripheral organs, or reside in tissues where cancers develop. In this article, we will review studies from both pre-clinical mouse models and human patients to summarize the phenotype, distribution and unique features of each memory subset, and highlight specific roles of each subset in anti-tumor immunity. Moreover, we will discuss how stem-cell like and resident memory CD8(+) T cell subsets relate to exhausted tumor-infiltrating lymphocytes (TIL) populations. These studies reveal how memory CD8(+) T cell subsets together orchestrate durable immunity to cancer.

引用

页数：10

共 145 条

[31] Human memory T cells: generation, compartmentalization and homeostasis [J].

Farber, Donna L. ;

Yudanin, Naomi A. ;

Restifo, Nicholas P. .

NATURE REVIEWS IMMUNOLOGY, 2014, 14 (01) :24-35

[32] Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection [J].

Fernandez-Ruiz, Daniel ;

Ng, Wei Yi ;

Holz, Lauren E. ;

Ma, Joel Z. ;

Zaid, Ali ;

Wong, Yik Chun ;

Lau, Lei Shong ;

Mollard, Vanessa ;

Cozijnsen, Anton ;

Collins, Nicholas ;

Li, Jessica ;

Davey, Gayle M. ;

Kato, Yu ;

Devi, Sapna ;

Skandari, Roghieh ;

Pauley, Michael ;

Manton, Jonathan H. ;

Godfrey, Dale I. ;

Braun, Asolina ;

Tay, Szun Szun ;

Tan, Peck Szee ;

Bowen, David G. ;

Koch-Nolte, Friedrich ;

Rissiek, Bjoern ;

Carbone, Francis R. ;

Crabb, Brendan S. ;

Lahoud, Mireille ;

Cockburn, Ian A. ;

Mueller, Scott N. ;

Bertolino, Patrick ;

McFadden, Geoffrey I. ;

Caminschi, Irina ;

Heath, William R. .

IMMUNITY, 2016, 45 (04) :889-902

[33] Developmental plasticity allows outside-in immune responses by resident memory T cells [J].

Fonseca, Raissa ;

Beura, Lalit K. ;

Quarnstrom, Clare F. ;

Ghoneim, Hazem E. ;

Fan, Yiping ;

Zebley, Caitlin C. ;

Scott, Milcah C. ;

Fares-Frederickson, Nancy J. ;

Wijeyesinghe, Sathi ;

Thompson, Emily A. ;

Borges da Silva, Henrique ;

Vezys, Vaiva ;

Youngblood, Benjamin ;

Masopust, David .

NATURE IMMUNOLOGY, 2020, 21 (04) :412-+

[34] CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs [J].

Förster, R ;

Schubel, A ;

Breitfeld, D ;

Kremmer, E ;

Renner-Müller, I ;

Wolf, E ;

Lipp, M .

CELL, 1999, 99 (01) :23-33

[35] Vaccination-induced skin-resident memory CD8+ T cells mediate strong protection against cutaneous melanoma [J].

Galvez-Cancino, Felipe ;

Lopez, Ernesto ;

Menares, Evelyn ;

Diaz, Ximena ;

Flores, Camila ;

Caceres, Pablo ;

Hidalgo, Sofia ;

Chovar, Ornella ;

Alcantara-Hernandez, Marcela ;

Borgna, Vincenzo ;

Varas-Godoy, Manuel ;

Salazar-Onfray, Flavio ;

Idoyaga, Juliana ;

Lladser, Alvaro .

ONCOIMMUNOLOGY, 2018, 7 (07)

[36] Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer [J].

Ganesan, Anusha-Preethi ;

Clarke, James ;

Wood, Oliver ;

Garrido-Martin, Eva M. ;

Chee, Serena J. ;

Mellows, Toby ;

Samaniego-Castruita, Daniela ;

Singh, Divya ;

Seumois, Gregory ;

Alzetani, Aiman ;

Woo, Edwin ;

Friedmann, Peter S. ;

King, Emma V. ;

Thomas, Gareth J. ;

Sanchez-Elsner, Tilman ;

Vijayanand, Pandurangan ;

Ottensmeier, Christian H. .

NATURE IMMUNOLOGY, 2017, 18 (08) :940-+

[37] T memory stem cells in health and disease [J].

Gattinoni, Luca ;

Speiser, Daniel E. ;

Lichterfeld, Mathias ;

Bonini, Chiara .

NATURE MEDICINE, 2017, 23 (01) :18-27

[38] Paths to stemness: building the ultimate antitumour T cell [J].

Gattinoni, Luca ;

Klebanoff, Christopher A. ;

Restifo, Nicholas P. .

NATURE REVIEWS CANCER, 2012, 12 (10) :671-684

[39] A human memory T cell subset with stem cell-like properties [J].

Gattinoni, Luca ;

Lugli, Enrico ;

Ji, Yun ;

Pos, Zoltan ;

Paulos, Chrystal M. ;

Quigley, Maire F. ;

Almeida, Jorge R. ;

Gostick, Emma ;

Yu, Zhiya ;

Carpenito, Carmine ;

Wang, Ena ;

Douek, Daniel C. ;

Price, David A. ;

June, Carl H. ;

Marincola, Francesco M. ;

Roederer, Mario ;

Restifo, Nicholas P. .

NATURE MEDICINE, 2011, 17 (10) :1290-U325

[40] Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells [J].

Gattinoni, Luca ;

Zhong, Xiao-Song ;

Palmer, Douglas C. ;

Ji, Yun ;

Hinrichs, Christian S. ;

Yu, Zhiya ;

Wrzesinski, Claudia ;

Boni, Andrea ;

Cassard, Lydie ;

Garvin, Lindsay M. ;

Paulos, Chrystal M. ;

Muranski, Pawel ;

Restifo, Nicholas P. .

NATURE MEDICINE, 2009, 15 (07) :808-U129

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