Memory CD8+ T cell responses to cancer

被引：131

作者：

Han, Jichang ^{[1
]}

Khatwani, Nikhil ^{[1
]}

Searles, Tyler G. ^{[2
]}

Turk, Mary Jo ^{[1
,2
]}

Angeles, Christina, V ^{[3
,4
]}

机构：

[1] Geisel Sch Med Dartmouth, Dept Microbiol & Immunol, Lebanon, NH 03756 USA

[2] Geisel Sch Med Dartmouth, Norris Cotton Canc Ctr, Lebanon, NH 03756 USA

[3] Univ Michigan, Sch Med, Dept Surg, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Comprehens Canc Ctr, Ann Arbor, MI 48109 USA

来源：

SEMINARS IN IMMUNOLOGY | 2020年 / 49卷

关键词：

Resident memory (T-RM); Stem cell memory (T-SCM); Effector memory (T-EM); Central memory (T-CM); Tumor immunity; Exhaustion; TISSUE-RESIDENT MEMORY; TUMOR-INFILTRATING LYMPHOCYTES; STEM-CELLS; CUTTING EDGE; IN-VIVO; NONLYMPHOID TISSUES; PROGNOSTIC-FACTOR; IMMUNE-RESPONSE; EFFECTOR; DIFFERENTIATION;

D O I：

10.1016/j.smim.2020.101435

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Long-lived memory CD8(+) T cells play important roles in tumor immunity. Studies over the past two decades have identified four subsets of memory CD8(+) T cells - central, effector, stem-like, and tissue resident memory - that either circulate through blood, lymphoid and peripheral organs, or reside in tissues where cancers develop. In this article, we will review studies from both pre-clinical mouse models and human patients to summarize the phenotype, distribution and unique features of each memory subset, and highlight specific roles of each subset in anti-tumor immunity. Moreover, we will discuss how stem-cell like and resident memory CD8(+) T cell subsets relate to exhausted tumor-infiltrating lymphocytes (TIL) populations. These studies reveal how memory CD8(+) T cell subsets together orchestrate durable immunity to cancer.

引用

页数：10

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