Comparative photophysical study of disulfonated aluminum phthalocyanine in unilamellar vesicles and leukemic K562 cells

被引：25
作者：
Dhami, S
Rumbles, G
MacRobert, AJ
Phillips, D
机构：
[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED, DEPT CHEM, LONDON SW7 2AY, ENGLAND
[2] UCL, SCH MED, RAYNE INST, LONDON, ENGLAND
来源：
PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1997年 / 65卷 / 01期
关键词：
D O I：
10.1111/j.1751-1097.1997.tb01881.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The photophysical properties of cis-disulfonated aluminum phthalocyanine (AlPcS(2)) in unilamellar vesicles (liposomes) of DL-alpha-dipalmitoyl-phosphatidylcholine have been measured, Both the fluorescence and triplet quantum yields decreased with increasing sensitizer concentration, The time-resolved fluorescence decays, analysed by both the sum of exponentials and decay time distribution analyses, are compared with those reported for AlPcS(2) in leukemic K562 cells. Information on the photodynamic transport and localization mechanism has been obtained by drawing correlations between the two systems, indicating active transport of the phthalocyanine into tumor cells involving lysosomal accumulation.
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页码：85 / 90
页数：6
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