Lipoprotein and metabolite associations to breast cancer risk in the HUNT2 study

被引:14
作者
Debik, Julia [1 ]
Schaefer, Hartmut [2 ]
Andreassen, Trygve [1 ]
Wang, Feng [1 ,3 ]
Fang, Fang [2 ]
Cannet, Claire [2 ]
Spraul, Manfred [2 ]
Bathen, Tone F. [1 ,4 ]
Giskeodegard, Guro F. [3 ,4 ,5 ]
机构
[1] Norwegian Univ Sci & Technol, Dept Circulat & Med Imaging, Trondheim, Norway
[2] Bruker BioSpin, AIC Div, Ettlingen, Germany
[3] Trondheim Reg & Univ Hosp, St Olays Hosp, Clin Surg, Trondheim, Norway
[4] Trondheim Reg & Univ Hosp, St Olays Hosp, Dept Radiol & Nucl Med, Trondheim, Norway
[5] Norwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Trondheim, Norway
关键词
BODY-MASS INDEX; SEX-HORMONES; COLLABORATIVE REANALYSIS; POSTMENOPAUSAL WOMEN; METABOLOMICS; SERUM; THERAPY; PROFILE; SPECTROSCOPY; ESTROGENS;
D O I
10.1038/s41416-022-01924-1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background The aim of this study was to gain an increased understanding of the aetiology of breast cancer, by investigating possible associations between serum lipoprotein subfractions and metabolites and the long-term risk of developing the disease. Methods From a cohort of 65,200 participants within the Trondelag Health Study (HUNT study), we identified all women who developed breast cancer within a 22-year follow-up period. Using nuclear magnetic resonance (NMR) spectroscopy, 28 metabolites and 89 lipoprotein subfractions were quantified from prediagnostic serum samples of future breast cancer patients and matching controls (n = 1199 case-control pairs). Results Among premenopausal women (554 cases) 14 lipoprotein subfractions were associated with long-term breast cancer risk. In specific, different subfractions of VLDL particles (in particular VLDL-2, VLDL-3 and VLDL-4) were inversely associated with breast cancer. In addition, inverse associations were detected for total serum triglyceride levels and HDL-4 triglycerides. No significant association was found in postmenopausal women. Conclusions We identified several associations between lipoprotein subfractions and long-term risk of breast cancer in premenopausal women. Inverse associations between several VLDL subfractions and breast cancer risk were found, revealing an altered metabolism in the endogenous lipid pathway many years prior to a breast cancer diagnosis.
引用
收藏
页码:1515 / 1524
页数:10
相关论文
共 54 条
[1]   Weight change in adulthood and risk of postmenopausal breast cancer: the HUNT study of Norway [J].
Alsaker, M. D. K. ;
Janszky, I. ;
Opdahl, S. ;
Vatten, L. J. ;
Romundstad, P. R. .
BRITISH JOURNAL OF CANCER, 2013, 109 (05) :1310-1317
[2]   Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development [J].
Baenke, Franziska ;
Peck, Barrie ;
Miess, Heike ;
Schulze, Almut .
DISEASE MODELS & MECHANISMS, 2013, 6 (06) :1353-1363
[3]   Feasibility of MR Metabolomics for Immediate Analysis of Resection Margins during Breast Cancer Surgery [J].
Bathen, Tone F. ;
Geurts, Brigitte ;
Sitter, Beathe ;
Fjosne, Hans E. ;
Lundgren, Steinar ;
Buydens, Lutgarde M. ;
Gribbestad, Ingrid S. ;
Postma, Geert ;
Giskeodegard, Guro F. .
PLOS ONE, 2013, 8 (04)
[4]   A Mendelian randomization analysis of circulating lipid traits and breast cancer risk [J].
Beeghly-Fadiel, Alicia ;
Khankari, Nikhil K. ;
Delahanty, Ryan J. ;
Shu, Xiao-Ou ;
Lu, Yingchang ;
Schmidt, Marjanka K. ;
Bolla, Manjeet K. ;
Michailidou, Kyriaki ;
Wang, Qin ;
Dennis, Joe ;
Yannoukakos, Drakoulis ;
Dunning, Alison M. ;
Pharoah, Paul D. P. ;
Chenevix-Trench, Georgia ;
Milne, Roger L. ;
Hunter, David J. ;
Per, Hall ;
Kraft, Peter ;
Simard, Jacques ;
Easton, Douglas F. ;
Zheng, Wei .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2020, 49 (04) :1117-1131
[5]   Prediagnostic circulating metabolites in female breast cancer cases with low and high mammographic breast density [J].
Bendinelli, Benedetta ;
Vignoli, Alessia ;
Palli, Domenico ;
Assedi, Melania ;
Ambrogetti, Daniela ;
Luchinat, Claudio ;
Caini, Saverio ;
Saieva, Calogero ;
Turano, Paola ;
Masala, Giovanna .
SCIENTIFIC REPORTS, 2021, 11 (01)
[6]  
Beral V, 1997, LANCET, V350, P1047, DOI 10.1016/S0140-6736(97)08233-0
[7]   The relation of age at menarche with age at natural menopause: a population study of 336 788 women in Norway [J].
Bjelland, E. K. ;
Hofvind, S. ;
Byberg, L. ;
Eskild, A. .
HUMAN REPRODUCTION, 2018, 33 (06) :1149-1157
[8]   Forecasting individual breast cancer risk using plasma metabolomics and biocontours [J].
Bro, Rasmus ;
Kamstrup-Nielsen, Maja H. ;
Engelsen, Soren Balling ;
Savorani, Francesco ;
Rasmussen, Morten A. ;
Hansen, Louise ;
Olsen, Anja ;
Tjonneland, Anne ;
Dragsted, Lars Ove .
METABOLOMICS, 2015, 11 (05) :1376-1380
[9]  
Cancer Registry of Norway, 2019, Cancer incidence and mortality (year 2017), incidence trend (2012-17) & estimates (2018-2021) for Tamilnadu state, Tamilnadu cancer registry project (TNCRP)
[10]   Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort [J].
Carayol, Marion ;
Leitzmann, Michael F. ;
Ferrari, Pietro ;
Zamora-Ros, Raul ;
Achaintre, David ;
Stepien, Magdalena ;
Schmidt, Julie A. ;
Travis, Ruth C. ;
Overvad, Kim ;
Tjonneland, Anne ;
Hansen, Louise ;
Kaaks, Rudolf ;
Kuehn, Tilman ;
Boein, Heiner ;
Bachlechner, Ursula ;
Trichoroulou, Antonia ;
Bamia, Christina ;
Palli, Domenico ;
Agnoli, Claudia ;
Tumino, Rosario ;
Vineis, Paolo ;
Panico, Salvatore ;
Quiros, J. Ramon ;
Sanchez-Cantalejo, Emilio ;
Huerta, Jose Maria ;
Ardanaz, Eva ;
Arriola, Larraitz ;
Agudo, Antonio ;
Nilsson, Jan ;
Melander, E. ;
Bueno-de-Mesquita, Bas ;
Peeters, Petra H. ;
Wareham, Nick ;
Khaw, Kay-Tee ;
Jenab, Mazda ;
Key, Timothy J. ;
Scalbert, Augustin ;
Rinaldi, Sabina .
JOURNAL OF PROTEOME RESEARCH, 2017, 16 (09) :3137-3146