Playing the Devil's advocate: is the Hodgkin-Huxley model useful?

被引:53
作者
Meunier, C [1 ]
Segev, I
机构
[1] Univ Paris 05, CNRS, UMR 8119, Lab Neurophys & Physiol Syst Moteur, F-75270 Paris 06, France
[2] Hebrew Univ Jerusalem, Dept Neurobiol, Inst Life Sci, IL-91904 Jerusalem, Israel
[3] Hebrew Univ Jerusalem, Interdisciplinary Ctr Neural Computat, IL-91904 Jerusalem, Israel
关键词
D O I
10.1016/S0166-2236(02)02278-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Hodgkin and Huxley (H-H) model for action potential generation has held firm for half a century because this relatively simple and experimentally testable model embodies the major features of membrane nonlinearity: namely, voltage-dependent ionic currents that activate and inactivate in time. However, experimental and theoretical developments of the past 20 years force one to re-evaluate its usefulness. First, the H-H model is, in its original form, limited to the two voltage-dependent currents found in the squid giant axon and it must be extended significantly if it is to deal with the excitable soma and dendrites of neurons. Second, the macroscopic and deterministic H-H model does not capture correctly the kinetics of the Na+ channel and it cannot account for the stochastic response to current injection that arises from the discrete nature of ion channels. Third, much simpler integrate-and-fire-type models seem to be more useful for exploring collective phenomena in neuronal networks. Is the H-H model threatened, or will it continue to set the fundamental framework for exploring neuronal excitability?
引用
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页码:558 / 563
页数:6
相关论文
共 49 条
[1]  
ABBOTT LF, STAT MECH NEURAL NET, P5
[2]  
[Anonymous], 1992, CHANCE DESIGN
[3]   INACTIVATION OF SODIUM CHANNEL .2. GATING CURRENT EXPERIMENTS [J].
ARMSTRONG, CM ;
BEZANILLA, F .
JOURNAL OF GENERAL PHYSIOLOGY, 1977, 70 (05) :567-590
[4]   Voltage-gated ion channels and electrical excitability [J].
Armstrong, CM ;
Hille, B .
NEURON, 1998, 20 (03) :371-380
[5]   INACTIVATION OF SODIUM CHANNEL .1. SODIUM CURRENT EXPERIMENTS [J].
BEZANILLA, F ;
ARMSTRONG, CM .
JOURNAL OF GENERAL PHYSIOLOGY, 1977, 70 (05) :549-566
[6]  
BORGGRAHAM LJ, 1991, CELLULAR MOL NEUROBI
[7]   Frequency control in synchronized networks of inhibitory neurons [J].
Chow, CC ;
White, JA ;
Ritt, J ;
Kopell, N .
JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 1998, 5 (04) :407-420
[8]  
Cole K., 1968, MEMBRANE IONS IMPULS
[9]   Electric impedance of the squid giant axon during activity [J].
Cole, KS ;
Curtis, HJ .
JOURNAL OF GENERAL PHYSIOLOGY, 1939, 22 (05) :649-670
[10]   DIFITAL COMPUTER SOLUTIONS FOR EXCITATION AND PROPAGATION OF NERVE IMPULSE [J].
COOLEY, JW ;
DODGE, FA .
BIOPHYSICAL JOURNAL, 1966, 6 (05) :583-&