Transfer hydrogenative reductive amination of aldehydes in aqueous sodium formate solution

被引：8

作者：

Zhu, Mengping ^{[1
]}

机构：

[1] Georgetown Univ, Dept Chem, Washington, DC 20057 USA

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 04期

关键词：

Aqueous; Reductive amination; Transfer hydrogenation; Ruthenium; Sodium formate; ASYMMETRIC TRANSFER HYDROGENATION; CARBONYL-COMPOUNDS; PRIMARY/SECONDARY AMINES; WATER; KETONES; CATALYST; COMPLEXES; ALCOHOLS; AMMONIA; MEDIA;

D O I：

10.1016/j.tetlet.2015.12.072

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical direct reductive amination reaction of aldehydes in aqueous sodium formate solution which produces amines in good yields under mild conditions is described. The amount and strength of the acid additives were critical factors to affect the reaction selectivities. This reductive amination method has great application potential for the synthesis of amine products given the mild conditions, short reaction time, the use of water as a solvent, and the use of benign hydrogen sources. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：509 / 511

页数：3

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