Cytochrome c release from mitochondria:: all or nothing

被引：299

作者：

Martinou, JC

Desagher, S

Antonsson, B

机构：

[1] Serono Pharmaceut Res Inst, CH-1228 Plan Les Quates, Switzerland

[2] CNRS, UPR 9023 CCIPE, F-34094 Montpellier 5, France

来源：

NATURE CELL BIOLOGY | 2000年 / 2卷 / 03期

关键词：

D O I：

10.1038/35004069

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During the process of apoptosis, cytochrome c is released from mitochondria into the cytosol where it helps to activate the caspases, a family of killer proteases. The release of cytochrome c is a rapid, complete and kinetically invariant event.

引用

页码：E41 / E43

页数：3

共 11 条

[1] Inhibition of Bax channel-forming activity by Bcl-2 [J].

Antonsson, B ;

Conti, F ;

Ciavatta, A ;

Montessuit, S ;

Lewis, S ;

Martinou, I ;

Bernasconi, L ;

Bernard, A ;

Mermod, JJ ;

Mazzei, G ;

Maundrell, K ;

Gambale, F ;

Sadoul, R ;

Martinou, JC .

SCIENCE, 1997, 277 (5324) :370-372

[2] Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations [J].

Basañez, G ;

Nechushtan, A ;

Drozhinin, O ;

Chanturiya, A ;

Choe, E ;

Tutt, S ;

Wood, KA ;

Hsu, YT ;

Zimmerberg, J ;

Youle, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (10) :5492-5497

[3] Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions [J].

Eskes, R ;

Antonsson, B ;

Osen-Sand, A ;

Montessuit, S ;

Richter, C ;

Sadoul, R ;

Mazzei, G ;

Nichols, A ;

Martinou, JC .

JOURNAL OF CELL BIOLOGY, 1998, 143 (01) :217-224

[4] The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant [J].

Goldstein, JC ;

Waterhouse, NJ ;

Juin, P ;

Evan, GI ;

Green, DR .

NATURE CELL BIOLOGY, 2000, 2 (03) :156-162

[5] Mitochondrial depolarization accompanies cytochrome c release during apoptosis in PC6 cells [J].

Heiskanen, KM ;

Bhat, MB ;

Wang, HW ;

Ma, JJ ;

Nieminen, AL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (09) :5654-5658

[6] Bax directly induces release of cytochrome c from isolated mitochondria [J].

Jürgensmeier, JM ;

Xie, ZH ;

Deveraux, Q ;

Ellerby, L ;

Bredesen, D ;

Reed, JC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (09) :4997-5002

[7] The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol [J].

Kluck, RM ;

Esposti, MD ;

Perkins, G ;

Renken, C ;

Kuwana, T ;

Bossy-Wetzel, E ;

Goldberg, M ;

Allen, T ;

Barber, MJ ;

Green, DR ;

Newmeyer, DD .

JOURNAL OF CELL BIOLOGY, 1999, 147 (04) :809-822

[8] Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis [J].

Marzo, I ;

Brenner, C ;

Zamzami, N ;

Jürgensmeier, JM ;

Susin, SA ;

Vieira, HLA ;

Prévost, MC ;

Xie, ZH ;

Matsuyama, S ;

Reed, JC ;

Kroemer, G .

SCIENCE, 1998, 281 (5385) :2027-2031

[9] Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2 [J].

Schlesinger, PH ;

Gross, A ;

Yin, XM ;

Yamamoto, K ;

Saito, M ;

Waksman, G ;

Korsmeyer, SJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (21) :11357-11362

[10] Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC [J].

Shimizu, S ;

Narita, M ;

Tsujimoto, Y .

NATURE, 1999, 399 (6735) :483-487

← 1 2 →