Oxidative stress is one of the major causes of cellular senescence in mammalian cells. The excess amount of reactive oxygen species generated by oxygen metabolism is pathogenic and facilitates tissue aging. Lung tissue is more susceptible to oxidative stress than other organs because it is directly exposed to environmental stresses. The aging of lung tissues increases the risk of chronic diseases. Senescent cells accumulate in tissues during aging and contribute to aging-associated morbidity; however, the roles of cellular senescence in lung aging and diseases have not yet been elucidated in detail. To clarify the physiological role of oxidative stress-induced cellular senescence in aging-associated declines in pulmonary function, we herein investigated the effects of the antioxidant N-acetyl-Lcysteine (NAC) on lung cellular senescence and aging in mice. The administration of NAC to 1-year-old mice reduced the expression of senescence-associated genes in lung tissue. Pulmonary function and lung morphology were partly restored in mice administered NAC. Collectively, these results suggest that oxidative stress is a major inducer of cellular senescence in vivo and that the control of oxidative stress may prevent lung aging and diseases. (C) 2021 Elsevier Inc. All rights reserved.
机构:
Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USAUniv Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Coppe, Jean -Philippe
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Desprez, Pierre-Yves
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机构:
Ruck Inst Age Res, Novato, CA 94945 USA
Calif Pacific Med Ctr, Canc Res Inst, San Francisco, CA 94107 USAUniv Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Desprez, Pierre-Yves
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Krtolica, Ana
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Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USAUniv Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Krtolica, Ana
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Campisi, Judith
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机构:
Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Ruck Inst Age Res, Novato, CA 94945 USAUniv Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
机构:
Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292
Dryden Jr. G.W.
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Deaciuc I.
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Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292
Deaciuc I.
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Arteel G.
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h-index: 0
机构:
Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292
Arteel G.
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McClain C.J.
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h-index: 0
机构:
Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292
机构:
Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USAUniv Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Coppe, Jean -Philippe
;
Desprez, Pierre-Yves
论文数: 0引用数: 0
h-index: 0
机构:
Ruck Inst Age Res, Novato, CA 94945 USA
Calif Pacific Med Ctr, Canc Res Inst, San Francisco, CA 94107 USAUniv Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Desprez, Pierre-Yves
;
Krtolica, Ana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USAUniv Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Krtolica, Ana
;
Campisi, Judith
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
Ruck Inst Age Res, Novato, CA 94945 USAUniv Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
机构:
Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292
Dryden Jr. G.W.
;
Deaciuc I.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292
Deaciuc I.
;
Arteel G.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292
Arteel G.
;
McClain C.J.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292