A Review: The Bioactivities and Pharmacological Applications of Polygonatum sibiricum polysaccharides

被引：242

作者：

Cui, Xiaowei ^{[1
]}

Wang, Shiyuan ^{[2
]}

Cao, Hui ^{[1
]}

Guo, Hong ^{[1
]}

Li, Yujuan ^{[1
]}

Xu, Fangxue ^{[1
]}

Zheng, Mengmeng ^{[1
]}

Xi, Xiaozhi ^{[1
]}

Han, Chunchao ^{[1
]}

机构：

[1] Shandong Univ Tradit Chinese Med, Sch Pharm, Jinan 250355, Shandong, Peoples R China

[2] Shandong Univ Tradit Chinese Med, Sch Tradit Chinese Med, Jinan 250355, Shandong, Peoples R China

来源：

MOLECULES | 2018年 / 23卷 / 05期

关键词：

Polygonatum sibiricum polysaccharides (PSP); compositions; pharmacological applications; biological activity; biosythesis; prospects; ANTI-FATIGUE ACTIVITY; ALZHEIMERS-DISEASE; GENUS POLYGONATUM; ANTIOXIDANT; RHIZOME; GLUCOSE; GROWTH;

D O I：

10.3390/molecules23051170

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Traditional Chinese Medicine (TCM) has been widely used in China and is regarded as the most important therapeutic. Polygonatum sibiricum (PS), a natural plant used in traditional Chinese medicine, has various functions associated with a number of its components. There are many compositions in PS including polysaccharides, steroids, anthraquinone, alkaloids, cardiac glycosides, lignin, vitamins, various acids, and so on. Of these, polysaccharides play a significant role in PS-based therapeutics. This article summarizes Polygonatum sibiricum polysaccharides (PSP) have many pharmacological applications and biological activities, such as their antioxidant activity, anti-aging activity, an anti-fatigue effect, immunity enhancement effect, antibacterial effect, anti-inflammatory effect, hypolipidemic and antiatherosclerotic effects, anti-osteoporosis effect, liver protection, treatment of diabetes mellitus (DM), anti-cancer effect, and may help prevent Alzheimer's disease, and so on. This review summarized the extraction method, purification method, compositions, pharmacological applications, biological activities, biosynthesis, and prospects of PSP, providing a basis for further study of PS and PSP.

引用

页数：12

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