Androgen-induced lncRNA POTEF-AS1 regulates apoptosis-related pathway to facilitate cell survival in prostate cancer cells

被引：30

作者：

Misawa, Aya ^{[1
]}

Takayama, Ken-ichi ^{[2
]}

Fujimura, Tetsuya ^{[3
]}

Homma, Yukio ^{[3
]}

Suzuki, Yutaka ^{[4
]}

Inoue, Satoshi ^{[1
,2
,5
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Anti Aging Med, Tokyo, Japan

[2] Tokyo Metropolitan Inst Gerontol, Dept Funct Biogerontol, Tokyo, Japan

[3] Univ Tokyo, Grad Sch Med, Dept Urol, Tokyo, Japan

[4] Univ Tokyo, Grad Sch Frontier Sci, Dept Med Genome Sci, Chiba, Japan

[5] Saitama Med Univ, Div Gene Regulat & Signal Transduct, Res Ctr Genom Med, Saitama, Japan

来源：

CANCER SCIENCE | 2017年 / 108卷 / 03期

基金：

日本学术振兴会;

关键词：

AR; lncRNA; prostate cancer; TLR3; TNFSF10; NONCODING RNA; BREAST-CANCER; PROGRESSION; RECEPTOR; POTE; TRANSCRIPTION; EXPRESSION; GROWTH; TESTIS;

D O I：

10.1111/cas.13151

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although long non-coding RNAs (lncRNAs) have been associated with a variety of cancers, the interplay between lncRNAs and androgen receptor signaling in prostate cancer is still unclear. We identified an androgen-dependent lncRNA, POTEF-AS1, whose expression was regulated by androgen receptor in two androgen- dependent cells by using directional RNA sequencing analysis. POTEF-AS1 promoted cell growth, repressed genes related to the Toll-like receptor signaling and apoptosis pathways, and inhibited apoptosis in docetaxel-treated LNCaP cells. These findings suggest that POTEF-AS1 would play a key role in the progression of prostate cancer by repressing Toll-like receptor signaling.

引用

页码：373 / 379

页数：7

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