The effects of carvedilol, metoprolol and propranolol on cisplatin-induced kidney injury

被引:10
作者
Esmaeeli, Abdolhamid [1 ]
Keshavarz, Zahra [1 ]
Dehdar, Firoozeh [2 ]
Assadi, Majid [2 ]
Seyedabadi, Mohammad [3 ,4 ]
机构
[1] Bushehr Univ Med Sci, Sch Med, Dept Pathol, Bushehr, Iran
[2] Bushehr Univ Med Sci, Persian Gulf Nucl Med Res Ctr, Bushehr Med Univ Hosp, Dept Mol Imaging & Radionuclide Therapy MIRT, Bushehr, Iran
[3] Mazandaran Univ Med Sci, Fac Pharm, Dept Toxicol & Pharmacol, Sari, Iran
[4] Mazandaran Univ Med Sci, Fac Pharm, Pharmaceut Sci Res Ctr, Sari, Iran
关键词
Carvedilol; metoprolol and propranolol; β -adrenoceptor; cisplatin; nephrotoxicity; biased ligand; INDUCED NEPHROTOXICITY; RENAL SCINTIGRAPHY; OXIDATIVE STRESS; TC-99M-DMSA; TOXICITY; NEPHROPROTECTION; ANTIOXIDANT; MECHANISMS; RECEPTORS; CAPTOPRIL;
D O I
10.1080/01480545.2020.1846551
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The beta-adrenoceptor blockers may have anti-oxidant properties or induce beta-arrestin recruitment beyond classical desensitization of receptor/G protein coupling, offering potential therapeutic benefits. Here, we investigated the effects of carvedilol, metoprolol and propranolol in an animal model of cisplatin-induced nephrotoxicity. Rats received the beta-blockers (3 or 12 mg/kg/day) with or without cisplatin, and kidney function was investigated using renal scintigraphy, histopathology, and serum variables. Metoprolol and propranolol as well as low-dose carvedilol did not alter kidney function, per se. Meanwhile, high-dose carvedilol reduced renal accumulation of Technetium-99m (99mTc)-labeled dimercaptosuccinic acid (99mTc-DMSA) without significant effect on other variables. Furthermore, low-dose carvedilol prevented cisplatin-induced reduction of tracer uptake, but high-dose of this drug aggravated the situation. In this regard, both low and high -doses of carvedilol significantly inhibited cisplatin effects on kidney histology, BUN and creatinine levels. Also, high-dose propranolol inhibited cisplatin adverse effects on radiotracer uptake, histological manifestations, BUN and creatinine levels, while metoprolol failed to cause a notable effect. Taken together, carvedilol and high-dose propranolol may offer potential benefits in cisplatin nephrotoxicity.
引用
收藏
页码:1558 / 1564
页数:7
相关论文
共 47 条
[1]   Co-supplementation of single and multi doses of vitamins C and E ameliorates cisplatin-induced acute renal failure in mice [J].
Ajith, T. A. ;
Abhishek, G. ;
Roshny, D. ;
Sudheesh, N. P. .
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 2009, 61 (06) :565-571
[2]   Cisplatin-induced cell death is EGFR/src/ERK signaling dependent in mouse proximal tubule cells [J].
Arany, I ;
Megyesi, JK ;
Kaneto, H ;
Price, PM ;
Safirstein, RL .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2004, 287 (03) :F543-F549
[3]   The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors [J].
Baker, JG .
BRITISH JOURNAL OF PHARMACOLOGY, 2005, 144 (03) :317-322
[4]   Nephroprotection by theophylline in patients with cisplatin chemotherapy: A randomized, single-blinded, placebo-controlled trial [J].
Benoehr, P ;
Krueth, P ;
Bokemeyer, C ;
Grenz, A ;
Osswald, H ;
Hartmann, JT .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2005, 16 (02) :452-458
[5]   Carvedilol protects against cisplatin-induced oxidative stress, redox state unbalance and apoptosis in rat kidney mitochondria [J].
Carvalho Rodrigues, M. A. ;
Rodrigues, J. L. ;
Martins, N. M. ;
Barbosa, F. ;
Curti, C. ;
Santos, N. A. G. ;
Santos, A. C. .
CHEMICO-BIOLOGICAL INTERACTIONS, 2011, 189 (1-2) :45-51
[6]   Protective effects of apocynin against cisplatin-induced oxidative stress and nephrotoxicity [J].
Chirino, Yolanda I. ;
Sanchez-Gonzalez, Dolores Javier ;
Martinez-Martinez, Claudia Maria ;
Cruz, Cristino ;
Pedraza-Chaverri, Jose .
TOXICOLOGY, 2008, 245 (1-2) :18-23
[7]  
El-Sayed ESM, 2008, PAK J PHARM SCI, V21, P255
[8]   Low-dose angiotensin AT1 receptor β-arrestin-biased ligand, TRV027, protects against cisplatin-induced nephrotoxicity [J].
Esmaeeli, Abdolhamid ;
Ebrahimi, Fatemeh ;
Tanha, Kaveh ;
Assadi, Majid ;
Seyedabadi, Mohammad .
PHARMACOLOGICAL REPORTS, 2020, 72 (06) :1676-1684
[9]   Comparison of 99mTc-DMSA renal scintigraphy with biochemical and histopathological findings in animal models of acute kidney injury [J].
Fatemikia, Hossein ;
Seyedabadi, Mohammad ;
Karimi, Zynab ;
Tanha, Kiarash ;
Assadi, Majid ;
Tanha, Kaveh .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2017, 434 (1-2) :163-169
[10]   Antioxidant activity of β-blockers:: An effect mediated by scavenging reactive oxygen and nitrogen species? [J].
Gomes, Ana ;
Costa, David ;
Lima, Jose L. F. C. ;
Fernandes, Eduarda .
BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (13) :4568-4577