NANOMEDICINE AFM tackles osteoarthritis

被引：22

作者：

Aigner, Thomas ^{[1
]}

Schmitz, Nicole ^{[1
]}

Haag, Jochen ^{[1
]}

机构：

[1] Inst Pathol, D-04103 Leipzig, Germany

来源：

NATURE NANOTECHNOLOGY | 2009年 / 4卷 / 03期

关键词：

CARTILAGE;

D O I：

10.1038/nnano.2009.29

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Current diagnostic tools detect cartilage degeneration only at advanced stages, but the atomic force microscope can now detect structural changes earlier, paving the way for treatment of joint diseases.

引用

页码：144 / 145

页数：2

共 8 条

[1] Suppression of cartilage matrix gene expression in upper zone chondrocytes of osteoarthritic cartilage [J].

Aigner, T ;

Vornehm, SI ;

Zeiler, G ;

Dudhia, J ;

vonderMark, K ;

Bayliss, MT .

ARTHRITIS AND RHEUMATISM, 1997, 40 (03) :562-569

[2] Il-1β and BMPS -: Interactive players of cartilage matrix degradation and regeneration [J].

Aigner, Thomas ;

Soeder, Stephan ;

Haag, Jochen .

EUROPEAN CELLS & MATERIALS, 2006, 12 :49-56

[3] Osteoarthritis [J].

Goldring, Mary B. ;

Goldring, Steven R. .

JOURNAL OF CELLULAR PHYSIOLOGY, 2007, 213 (03) :626-634

[4]

Poole A. Robin, 1999, Frontiers in Bioscience, V4, pd662, DOI 10.2741/Poole

[5] Dynamic elastic modulus of porcine articular cartilage determined at two different levels of tissue organization by indentation-type atomic force microscopy [J].

Stolz, M ;

Raiteri, R ;

Daniels, AU ;

VanLandingham, MR ;

Baschong, W ;

Aebi, U .

BIOPHYSICAL JOURNAL, 2004, 86 (05) :3269-3283

[6] Developing scanning probe-based nanodevices - stepping out of the laboratory into the clinic [J].

Stolz, Martin ;

Aebi, Ueli ;

Stoffler, Daniel .

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2007, 3 (01) :53-62

[7]

Stolz M, 2009, NAT NANOTECHNOL, V4, P186, DOI [10.1038/NNANO.2008.410, 10.1038/nnano.2008.410]

[8] Osteoarthritis - An untreatable disease? [J].

Wieland, HA ;

Michaelis, M ;

Kirschbaum, BJ ;

Rudolphi, KA .

NATURE REVIEWS DRUG DISCOVERY, 2005, 4 (04) :331-344

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