Phosphorylation of the liver X receptors

被引：53
作者：
Chen, Mingyi
Bradley, Michelle N.
Beaven, Simon W.
Tontonoz, Peter [1 ]
机构：
[1] Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Med, Div Digest Dis, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Sch Med, Howard Hughes Med Inst, Los Angeles, CA 90095 USA
来源：
FEBS LETTERS | 2006年 / 580卷 / 20期
关键词：
liver X receptor; cholesterol metabolism; phosphorylation;
D O I：
10.1016/j.febslet.2006.07.074
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The liver X receptors (LXRs) function as nutritional sensors for cholesterol and have important roles in lipid metabolism, glucose homeostasis, and inflammation. We provide the first evidence that LXRs are phosphorylated proteins. Mutational analysis and metabolic labeling indicate LXRm is phosphorylated on serine 198 in the hinge region. This is a consensus target for the MAPK family. A phosphorylation-deficient mutant, LXR alpha S198A, remains nuclear and responds to ligands like the wild-type protein. The biological significance of LXR phosphorylation remains to be elucidated but could provide a novel mechanism for the regulation of LXR signaling pathways and cellular metabolism. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：4835 / 4841
页数：7
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