Novel Findings of Anti-cancer Property of Propofol

被引：39
作者：
Wang, Jiaqiang [1 ,3 ]
Cheng, Chien-shan [2 ,3 ]
Lu, Yan [1 ,3 ]
Ding, Xiaowei [1 ,3 ]
Zhu, Minmin [1 ,3 ]
Miao, Changhong [1 ,3 ]
Chen, Jiawei [1 ,3 ]
机构：
[1] Fudan Univ, Shanghai Canc Ctr, Dept Anesthesiol, 270 DongAn Rd, Shanghai 200032, Peoples R China
[2] Fudan Univ, Shanghai Canc Ctr, Dept Integrat Oncol, 270 DongAn Rd, Shanghai 200032, Peoples R China
[3] Fudan Univ, Shanghai Med Coll, Dept Oncol, 270 DongAn Rd, Shanghai 200032, Peoples R China
来源：
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2018年 / 18卷 / 02期
关键词：
Propofol; anesthetic; general anesthesia; neoplasms; anti-cancer; malignance-modulating; PANCREATIC-CANCER CELLS; HEPATOCELLULAR-CARCINOMA CELLS; DOWN-REGULATION; IN-VITRO; SUPPRESSES PROLIFERATION; INHIBITS INVASION; INDUCED APOPTOSIS; UP-REGULATION; ISCHEMIA/REPERFUSION INJURY; TRANSCRIPTION FACTOR;
D O I：
10.2174/1871520617666170912120327
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Propofol, a widely used intravenous anesthetic agent, is traditionally applied for sedation and general anesthesia. Explanation: Recent attention has been drawn to explore the effect and mechanisms of propofol against cancer progression in vitro and in vivo. Specifically, the proliferation-inhibiting and apoptosis-inducing properties of propofol in cancer have been studied. However, the underlying mechanisms remain unclear. Conclusion: This review focused on the findings within the past ten years and aimed to provide a general overview of propofol's malignance-modulating properties and the potential molecular mechanisms.
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收藏
页码：156 / 165
页数：10
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