Isolation and Immunomodulatory Effect of Homoisoflavones and Flavones from Agave sisalana Perrine ex Engelm.

被引：37

作者：

Chen, Pi Yu ^{[4
]}

Kuo, Yuh Chi ^{[3
]}

Chen, Chin Hui ^{[4
]}

Kuo, Yueh Hsiung ^{[1
,2
]}

Lee, Ching Kuo ^{[4
]}

机构：

[1] China Med Univ, Tsutzki Inst Tradit Med, Taichung 40402, Taiwan

[2] Acad Sinica, Agr Biotechnol Res Ctr, Taipei 115, Taiwan

[3] Fu Jen Catholic Univ, Inst Life Sci, Taipei 24205, Taiwan

[4] Taipei Med Univ, Grad Inst Pharm, Taipei 11031, Taiwan

来源：

MOLECULES | 2009年 / 14卷 / 05期

关键词：

Agave sisalana Perrine ex Engelm; homoisoflavonoid; PBMC; IL-2; IFN-gamma; DRACAENA-LOUREIRI;

D O I：

10.3390/molecules14051789

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three known flavones and seven known homoisoflavonoids were isolated from the methanolic extract of the leaves of Agave sisalana Perrine ex Engelm. Their structures were elucidated on the basis of spectroscopic analysis. The isolated compounds were also evaluated for immunopharmacological activity. PBMC were used as target cells, and cell proliferation was determined by H-3-thymidine uptake. (+/-)-3,9-Dihydroeucomin (4), dihydrobonducellin (5), and 5,7-dihydroxy-3-(4'-hydroxybenzyl)-4-chromanone (7) showed inhibitory effects on PBMC proliferation activated by PHA with IC50 values 19.4, 73.8, and 58.8 mu M, respectively. All three compounds significantly inhibited the production of IL-2 and IFN-gamma in activated PBMC in a concentration-dependent manner.

引用

页码：1789 / 1795

页数：7

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