Anti-insulin-like growth factor-1 autoantibodies in type 1 diabetes

被引：0
|
作者：
Maruyama, T
Murayama, H
Nagata, A
Shimada, A
Kasuga, A
Saruta, T
机构：
[1] Saitama Social Insurance Hosp, Dept Internal Med, Saitamashi, Saitama 3360002, Japan
[2] Yamasa Co, Div Diagnost, Chiba 2880056, Japan
[3] Keio Univ, Sch Med, Dept Internal Med, Tokyo 1618582, Japan
来源：
IMMUNOLOGY OF DIABETES: AUTOIMMUNE MECHANISMS AND THE PREVENTION AND CURE OF TYPE 1 DIABETES | 2002年 / 958卷
关键词：
anti-insulin-like growth factor-1 autoantibodies; type 1 diabetes mellitus;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Insulin-like growth factor-1 (IGF-1) reportedly suppresses the development of type I diabetes in NOD mice, suggesting that IGF-1 is possibly a candidate for the autoantigens in type 1 diabetes. We therefore examined the anti-IGF-1 autoantibodies (IGF-1 Ab) in sera from patients with type I diabetes using radioimmunoassay. However, we were unable to demonstrate the existence of anti-IGF-1 autoantibodies in type 1 diabetes with our method. Further study is necessary to clarify whether anti-IGF-1 autoantibodies are existent in human type 1 diabetes and to determine the significance of IGF-1 in the pathogensesis of type I diabetes.
引用
收藏
页码：267 / 270
页数：4
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