Aptamers for Viral Detection and Inhibition

被引：30

作者：

Chakraborty, Banani ^{[2
]}

Das, Sreyashi ^{[1
]}

Gupta, Arushi ^{[2
]}

Xiong, Yanyu ^{[3
,4
]}

T-V, Vyshnavi ^{[2
]}

Kizer, Megan E. ^{[5
,6
]}

Duan, Jinwei ^{[7
]}

Chandrasekaran, Arun Richard ^{[8
]}

Wang, Xing ^{[4
,9
,10
,11
]}

机构：

[1] Indian Inst Technol, Dept Biol Sci & Bioengn, Kanpur 208016, Uttar Pradesh, India

[2] Indian Inst Sci, Dept Chem Engn, Bangalore 560012, Karnataka, India

[3] Univ Illinois, Dept Elect & Comp Engn, Urbana, IL 61801 USA

[4] Univ Illinois, Nick Holonyak Jr Micro & Nanotechnol Lab HMNTL, Urbana, IL 61801 USA

[5] MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[6] MIT, Dept Chem, Cambridge, MA 02139 USA

[7] Changan Univ, Dept Chem & Mat Sci, Xian 710064, Shaanxi, Peoples R China

[8] SUNY Albany, RNA Inst, Albany, NY 12222 USA

[9] Univ Illinois, Dept Bioengn, Urbana, IL 61801 USA

[10] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

[11] Univ Illinois, Carl R Woese Inst Genom Biol IGB, Urbana, IL 61801 USA

来源：

ACS INFECTIOUS DISEASES | 2022年 / 8卷 / 04期

关键词：

viruses; sensing; inhibition; aptamers; DNA nanostructures; aptasensors; HEPATITIS-C VIRUS; NEUTRALIZES R5 STRAINS; IN-VITRO SELECTION; QUARTET-FORMING OLIGONUCLEOTIDE; RECEPTOR-BINDING REGION; NUCLEIC-ACID APTAMERS; LEAF-CURL-VIRUS; RNA APTAMER; DNA APTAMERS; HIGH-AFFINITY;

D O I：

10.1021/acsinfecdis.1c00546

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Recent times have experienced more than ever the impact of viral infections in humans. Viral infections are known to cause diseases not only in humans but also in plants and animals. Here, we have compiled the literature review of aptamers selected and used for detection and inhibition of viral infections in all three categories: humans, animals, and plants. This review gives an in-depth introduction to aptamers, different types of aptamer selection(SELEX) methodologies, the benefits of using aptamers over commonly used antibody-basedstrategies, and the structural and functional mechanism of aptasensors for viral detection andtherapy. The review is organized based on the different characterization and read-out toolsused to detect virus-aptasensor interactions with a detailed index of existing virus-targetingaptamers. Along with addressing recent developments, we also discuss a way forward with aptamers for DNA nanotechnology-based detection and treatment of viral diseases. Overall, this review will serve as a comprehensive resource for aptamer-based strategies in viral diagnostics and treatment.

引用

页码：667 / 692

页数：26

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