Impact of repeated yearly vaccination on immune responses to influenza vaccine in an elderly population

Background: The effectiveness of repeated vaccination for seasonal influenza remains controversial. Here, we measured antibody responses to the influenza virus (A/H1N1, A/H3N2 and B) in a closed cohort of older participants vaccinated against influenza virus in each of 5 consecutive years. Methods: One hundred and 11 volunteers aged >61 years were vaccinated subcutaneously with 1 dose (0.5 ml) of inactivated influenza vaccine as recommended by the World Health Organization from the 2005-2006 season through the 2009-2010 season. Hemagglutination inhibition (HI) antibody titers were determined. Results: HI antibody titers against all 3 virus strains were significantly higher at 4 weeks after vaccination than at a time point prior to vaccination in each of the 5 seasons (P < .01); HI antibody titers were detected at the original prevaccination levels just prior to re-vaccination the following year. Sero-protection and HI antibody titers at 4 weeks after vaccination were similar against all influenza strains and during most of the 5 seasons evaluated. Vaccine strain changes were associated with specific immune responses in 9 of 12 (75%) intervals. Conclusions: Taken together, our results suggest that annual vaccination is necessary to maintain humoral immunity for the elderly population. Furthermore, our findings revealed that annual seasonal vaccination was not associated with reduced vaccine effectiveness, and that the reformation of the vaccine resulted in amplified immune responses among those undergoing yearly vaccination in the elderly population. (C) 2020 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.