CYP2E1 RsaI/PstI polymorphisms contributed to oral cancer susceptibility: a meta-analysis

被引：0

作者：

Guo, Yang ^{[1
]}

Zhou, Shan ^{[2
]}

Liu, Feng ^{[4
]}

Zhang, Bin ^{[3
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 2, Dept Endodont, Harbin 150086, Heilongjiang, Peoples R China

[2] Harbin Med Univ, Affiliated Hosp 2, Dept Orthodont, Harbin 150086, Heilongjiang, Peoples R China

[3] Harbin Med Univ, Affiliated Hosp 2, Dept Implantol, Harbin 150086, Heilongjiang, Peoples R China

[4] Harbin Childrens Hosp, Dept Stomatol, Harbin, Heilongjiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 11期

关键词：

CYP2E1; polymorphism; oral cancer; meta-analysis; SQUAMOUS-CELL CARCINOMA; UPPER AERODIGESTIVE TRACT; GENETIC POLYMORPHISMS; NECK-CANCER; METABOLIZING-ENZYMES; OROPHARYNGEAL CANCER; CYTOCHROME P-4502E1; ALCOHOL-CONSUMPTION; RISK; HEAD;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several studies have investigated the associations between CYP2E1 RsaI/PstI polymorphisms and oral cancer risk, but results have been inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. PubMed and China National Knowledge Infrastructure (CNKI) searches were carried out for relevant studies published before September 2014. Meta-analysis was performed with the Stata, version 11.0. A total of 14 case control studies, including 1,962 cases and 3,271 controls, were selected. Overall, significant association was found between the CYP2E1 RsaI/PstI polymorphisms and oral cancer risk (for c1c1 vs. c1c2, OR=0.72, 95% CI=0.56-0.91; for c1c1 vs. c2c2, OR=0.45, 95% CI=0.25-0.82), while not for the dominant model (c1c1 vs. c1c2+ c2c2, OR=0.84, 95% CI=0.69-1.01). In the subgroup analysis by ethnicity, statistically significant association was found in Caucasian, East Asian and South Asian. This meta-analysis suggests that the CYP2E1 RsaI/PstI polymorphisms are a risk factor for developing oral cancer.

引用

页码：14685 / 14692

页数：8

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