Synthesis of 11C-labeled 2-aminoethanol via a nitroaldol reaction using nitro[11C]methane

被引：3

作者：

Kato, Koichi ^{[1
]}

Zhang, Ming-Rong ^{[1
]}

Minegishi, Katsuyuki ^{[1
]}

Suzuki, Kazutoshi ^{[1
]}

机构：

[1] Natl Inst Radiol Sci, Dept Mol Probes, Inage Ku, Chiba 2638555, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 13期

关键词：

Positron emission tomography; Nitro[C-11]methane; 2-Aminoethanol; PROSTATE-CANCER; NITROALKANES; AMINES; C-11;

D O I：

10.1016/j.bmcl.2009.05.028

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The nitroaldol reaction of nitro[C-11] methane and formaldehyde using EtOH and EtONa efficiently provided 2-nitro[C-11] ethanol in 3 min. The nitro group reduction in the presence of NiCl2 and NaBH4 in MeOH followed by purification using semi-preparative HPLC using 10% EtOH aqueous solution as an eluent proved to be a practical and accessible method for the synthesis of 2-amino[2-C-11] ethanol. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3439 / 3441

页数：3

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