共 21 条
Sustained focal antitumor activity of bevacizumab in recurrent glioblastoma
被引:19
作者:

Baehr, Oliver
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dr Senckenberg Inst Neurooncol, D-60054 Frankfurt, Germany
German Canc Consortium DKTK, Heidelberg, Germany
German Canc Res Ctr, Heidelberg, Germany Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dr Senckenberg Inst Neurooncol, D-60054 Frankfurt, Germany

Harter, Patrick N.
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Univ Hosp Frankfurt, Inst Neurol, Edinger Inst, D-60054 Frankfurt, Germany
German Canc Consortium DKTK, Heidelberg, Germany
German Canc Res Ctr, Heidelberg, Germany Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dr Senckenberg Inst Neurooncol, D-60054 Frankfurt, Germany

Weise, Lutz M.
论文数: 0 引用数: 0
h-index: 0
机构:
Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dept Neurosurg, D-60054 Frankfurt, Germany
German Canc Consortium DKTK, Heidelberg, Germany
German Canc Res Ctr, Heidelberg, Germany Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dr Senckenberg Inst Neurooncol, D-60054 Frankfurt, Germany

You, Se-Jong
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h-index: 0
机构:
Goethe Univ Frankfurt, Univ Hosp Frankfurt, Inst Neuroradiol, D-60054 Frankfurt, Germany
German Canc Consortium DKTK, Heidelberg, Germany
German Canc Res Ctr, Heidelberg, Germany Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dr Senckenberg Inst Neurooncol, D-60054 Frankfurt, Germany

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Ronellenfitsch, Michael W.
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机构:
Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dr Senckenberg Inst Neurooncol, D-60054 Frankfurt, Germany
German Canc Consortium DKTK, Heidelberg, Germany
German Canc Res Ctr, Heidelberg, Germany Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dr Senckenberg Inst Neurooncol, D-60054 Frankfurt, Germany

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Steinbach, Joachim P.
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h-index: 0
机构:
Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dr Senckenberg Inst Neurooncol, D-60054 Frankfurt, Germany
German Canc Consortium DKTK, Heidelberg, Germany
German Canc Res Ctr, Heidelberg, Germany Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dr Senckenberg Inst Neurooncol, D-60054 Frankfurt, Germany

Hattingen, Elke
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h-index: 0
机构:
Goethe Univ Frankfurt, Univ Hosp Frankfurt, Inst Neuroradiol, D-60054 Frankfurt, Germany
German Canc Consortium DKTK, Heidelberg, Germany
German Canc Res Ctr, Heidelberg, Germany Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dr Senckenberg Inst Neurooncol, D-60054 Frankfurt, Germany
机构:
[1] Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dr Senckenberg Inst Neurooncol, D-60054 Frankfurt, Germany
[2] Goethe Univ Frankfurt, Univ Hosp Frankfurt, Inst Neurol, Edinger Inst, D-60054 Frankfurt, Germany
[3] Goethe Univ Frankfurt, Univ Hosp Frankfurt, Dept Neurosurg, D-60054 Frankfurt, Germany
[4] Goethe Univ Frankfurt, Univ Hosp Frankfurt, Inst Neuroradiol, D-60054 Frankfurt, Germany
[5] German Canc Consortium DKTK, Heidelberg, Germany
[6] German Canc Res Ctr, Heidelberg, Germany
来源:
关键词:
MALIGNANT GLIOMAS;
TUMOR PROGRESSION;
SURROGATE MARKER;
PATTERNS;
INVASION;
SURVIVAL;
EFFICACY;
RELAPSE;
D O I:
10.1212/WNL.0000000000000594
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
Objectives: To investigate the relevance of bevacizumab (BEV)-induced diffusion-restricted lesions and T1-hyperintense lesions in patients with recurrent glioblastoma. Methods: We prospectively screened 74 BEV-treated patients with recurrent glioblastoma for (1) diffusion-restricted lesions and/or, (2) lesions with a hyperintense signal on precontrast T1-weighted images. We further evaluated overall survival (OS), histopathology of the lesions, and patterns of progression. Results: Twenty-five of 74 patients (34%) developed T1-hyperintense lesions, whereas diffusion-restricted lesions could be detected in 35 of 74 patients (47%). In 21 of 74 patients (28%), the lesions displayed both features ("double-positive"). OS for patients with double-positive lesions was 13.0 months; patients with neither of these lesions had an OS of 6.6 months (p < 0.005). Histologic evaluation of double-positive lesions revealed extensive calcified necrosis in 4 of 4 patients. Notably, these double-positive lesions were rarely involved in further tumor progression. However, they were associated with an increase in distant recurrences at BEV failure. Conclusions: BEV-induced double-positive MRI lesions are a predictive imaging marker associated with a substantial survival benefit and with improved local control in patients with recurrent glioblastoma. Our data suggest that these lesions are the result of a sustained focal antitumor activity of BEV.
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页码:227 / 234
页数:8
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Acad Sci Czech Republic, Inst Sci Instruments, CS-61264 Brno, Czech Republic Ctr Rech Publ Sante, NorLux Neurooncol Lab, Dept Oncol, L-1526 Luxembourg, Luxembourg

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Wang, Jian
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Univ Bergen, Dept Biomed, N-5009 Bergen, Norway Ctr Rech Publ Sante, NorLux Neurooncol Lab, Dept Oncol, L-1526 Luxembourg, Luxembourg

Stieber, Daniel
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Ctr Rech Publ Sante, NorLux Neurooncol Lab, Dept Oncol, L-1526 Luxembourg, Luxembourg Ctr Rech Publ Sante, NorLux Neurooncol Lab, Dept Oncol, L-1526 Luxembourg, Luxembourg

Stuhr, Linda
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Univ Bergen, Dept Biomed, N-5009 Bergen, Norway Ctr Rech Publ Sante, NorLux Neurooncol Lab, Dept Oncol, L-1526 Luxembourg, Luxembourg

Moen, Ingrid
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Univ Bergen, Dept Biomed, N-5009 Bergen, Norway Ctr Rech Publ Sante, NorLux Neurooncol Lab, Dept Oncol, L-1526 Luxembourg, Luxembourg

Rygh, Cecilie Brekke
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Univ Bergen, Dept Biomed, N-5009 Bergen, Norway Ctr Rech Publ Sante, NorLux Neurooncol Lab, Dept Oncol, L-1526 Luxembourg, Luxembourg

Bjerkvig, Rolf
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Ctr Rech Publ Sante, NorLux Neurooncol Lab, Dept Oncol, L-1526 Luxembourg, Luxembourg
Univ Bergen, Dept Biomed, N-5009 Bergen, Norway Ctr Rech Publ Sante, NorLux Neurooncol Lab, Dept Oncol, L-1526 Luxembourg, Luxembourg

Niclou, Simone P.
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Ctr Rech Publ Sante, NorLux Neurooncol Lab, Dept Oncol, L-1526 Luxembourg, Luxembourg Ctr Rech Publ Sante, NorLux Neurooncol Lab, Dept Oncol, L-1526 Luxembourg, Luxembourg