Dendronized Cryptophanes as Water-Soluble Xenon Hosts for 129Xe Magnetic Resonance Imaging

被引：17
|
作者：
Tyagi, Rahul [1 ]
Witte, Christopher [2 ]
Haag, Rainer [1 ]
Schroeder, Leif [2 ]
机构：
[1] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany
[2] Leibniz Inst Mol Pharmakol FMP, ERC Project BiosensorImaging, Berlin, Germany
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 17期
基金：
欧洲研究理事会;
关键词：
NMR; BIOSENSOR;
D O I：
10.1021/ol501951z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Cryptophane cages are very promising for Xe-129-MRI. These molecular cages are extremely hydrophobic, which currently limits their use for diagnostic applications. To overcome this, the synthesis of water-soluble dendronized cryptophanes with surface groups for further functionalization is reported here. These molecules retained all the "core properties of cryptophane" that are crucial for biosensor applications as analyzed by Hyper-CEST imaging and spectroscopy. This approach is promising for developing new generations of xenon-cryptophane-based biosensors.
引用
收藏
页码：4436 / 4439
页数：4
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