Silver(II) oxide-mediated synthesis of 2,4-diarylquinazolines

被引：1
作者：
Cheung, Wing [1 ]
Patch, Raymond J. [1 ]
Player, Mark R. [1 ]
机构：
[1] Janssen Res & Dev, Cardiovasc & Metab TA, Welch & McKean Rd, Spring House, PA 19477 USA
来源：
TETRAHEDRON LETTERS | 2018年 / 59卷 / 24期
关键词：
Diarylquinazoline; N-arylbenzamidine; Silver oxide; Radical oxidation; ONE-POT SYNTHESIS; N BOND FORMATION; QUINAZOLINE DERIVATIVES; ACRIDONE ALKALOIDS; SOLVENT; 2-PHENYLQUINAZOLINES; FUNCTIONALIZATION; BENZIMIDAZOLES; AMINATION; OXIDATION;
D O I：
10.1016/j.tetlet.2018.05.019
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A single-pot procedure for the synthesis of 2,4-diarylquinazolines is described which involves a silver oxide-mediated C-H activation/C-N bond formation process. The generality of this method with respect to substituent effects is presented along with studies leading to process optimization. Mechanistic investigations provide support for the involvement of radical intermediates in the reaction process. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2368 / 2371
页数：4
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