Changes in Capsule and Drug Resistance of Pneumococci after Introduction of PCV7, Japan, 2010-2013

被引:81
作者
Chiba, Naoko [1 ,2 ]
Morozumi, Miyuki [1 ,2 ]
Shouji, Michi [3 ]
Wajima, Takeaki [4 ]
Iwata, Satoshi [1 ]
Ubukata, Kimiko [1 ,2 ]
机构
[1] Keio Univ, Sch Med, Tokyo 1608582, Japan
[2] Kitasato Univ, Tokyo, Japan
[3] Natl Canc Ctr, Tokyo, Japan
[4] Tokyo Univ Pharm & Life Sci, Tokyo, Japan
关键词
PENICILLIN-BINDING PROTEIN; STREPTOCOCCUS-PNEUMONIAE; CONJUGATE VACCINE; ANTIBIOTIC SUSCEPTIBILITY; SEROTYPE REPLACEMENT; UNITED-STATES; MACROLIDE; DISEASE; INFECTIONS; CHILDREN;
D O I
10.3201/eid2007.131485
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We aimed to clarify changes in serotypes and genotypes mediating beta-lactam and macrolide resistance in Streptococcus pneumoniae isolates from Japanese children who had invasive pneumococcal disease (IPD) after the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced into Japan; 341 participating general hospitals conducted IPD surveillance during April 2010 March 2013. A total of 300 pneumococcal isolates were collected in 2010, 146 in 2011, and 156 in 2012. The proportion of vaccine serotypes in infectious isolates decreased from 73.3% to 54.8% to 14.7% during the 3 years. Among vaccine serotype strains, genotypic penicillin-resistant S. pneumoniae strains also declined each year. Among nonvaccine serotype strains, 19A, 15A, 15B, 15C, and 24 increased in 2012. Increases were noted especially in genotypic penicillin-resistant S. pneumoniae isolates of serotypes 15A and 358, as well as macrolide resistance mediated by the erm(B) gene in 15A, 15B, 15C, and 24.
引用
收藏
页码:1132 / 1139
页数:8
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