Assembly of the Mycobacterial Cell Wall

被引：251

作者：

Jankute, Monika ^{[1
]}

Cox, Jonathan A. G. ^{[1
]}

Harrison, James ^{[1
]}

Besra, Gurdyal S. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

来源：

ANNUAL REVIEW OF MICROBIOLOGY, VOL 69 | 2015年 / 69卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

arabinogalactan; biosynthesis; cell wall; lipoarabinomannan; mycolic acids; peptidoglycan; MYCOLIC ACIDS; CORYNEBACTERIUM-GLUTAMICUM; PHOSPHATIDYLINOSITOL MANNOSIDES; LIPOARABINOMANNAN BIOSYNTHESIS; STRUCTURAL FEATURES; ARABINAN BIOSYNTHESIS; NONREDUCING TERMINI; N-GLYCOLYLATION; LENGTH CONTROL; CROSS-LINKING;

D O I：

10.1146/annurev-micro-091014-104121

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mycobacterium tuberculosis remains one of the most successful bacterial pathogens, claiming over 1.3 million lives worldwide in 2013. The emergence of multidrug-resistant and extensively drug-resistant isolates has prompted the need for new drugs and drug targets. M. tuberculosis possesses an unusual cell wall dominated by lipids and carbohydrates that provides a permeability barrier against hydrophilic drugs and is crucial for its survival and virulence. This large macromolecular structure, termed the mycolylarabinogalactan-peptidoglycan complex, and the phosphatidyl-myo-inositol based lipoglycans are key features of the mvcobacterial cell wall. Assembly of these cell wall components is an attractive target for the development of chemotherapeutics against tuberculosis. Herein, we focus on recent biochemical and molecular insights into these complex molecules of M. tuberculosis cell wall.

引用

页码：405 / 423

页数：19

共 129 条

[41] A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis [J].

Glickman, MS ;

Cox, JS ;

Jacobs, WR .

MOLECULAR CELL, 2000, 5 (04) :717-727

[42] The mmaA2 gene of Mycobacterium tuberculosis encodes the distal cycloproplane synthase of the α-mycolic acid [J].

Glickman, MS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (10) :7844-7849

[43] Lipomannan and lipoarabinomannan from a clinical isolate of Mycobacterium kansasii -: Novel structural features and apoptosis-inducing properties [J].

Guérardel, Y ;

Maes, E ;

Briken, V ;

Chirat, F ;

Leroy, Y ;

Locht, C ;

Strecker, G ;

Kremer, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (38) :36637-36651

[44] Structural study of lipomannan and lipoarabinomannan from Mycobacterium chelonae -: Presence of unusual components with α1,3-mannopyranose side chains [J].

Guérardel, Y ;

Maes, E ;

Elass, E ;

Leroy, Y ;

Timmerman, P ;

Besra, GS ;

Locht, C ;

Strecker, G ;

Kremer, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (34) :30635-30648

[45] Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria [J].

Guerin, Marcelo E. ;

Kordulakova, Jana ;

Schaeffer, Francis ;

Svetlikova, Zuzana ;

Buschiazzo, Alejandro ;

Giganti, David ;

Gicquel, Brigitte ;

Mikusova, Katarina ;

Jackson, Mary ;

Alzari, Pedro M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (28) :20705-20714

[46] New Insights into the Early Steps of Phosphatidylinositol Mannoside Biosynthesis in Mycobacteria PimB' IS AN ESSENTIAL ENZYME OF MYCOBACTERIUM SMEGMATIS [J].

Guerin, Marcelo E. ;

Kaur, Devinder ;

Somashekar, B. S. ;

Gibbs, Sara ;

Gest, Petra ;

Chatterjee, Delphi ;

Brennan, Patrick J. ;

Jackson, Mary .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (38) :25687-25696

[47] Interaction and Modulation of Two Antagonistic Cell Wall Enzymes of Mycobacteria [J].

Hett, Erik C. ;

Chao, Michael C. ;

Rubin, Eric J. .

PLOS PATHOGENS, 2010, 6 (07) :1-14

[48] Inactivation of the antigen 85C gene profoundly affects the mycolate content and alters the permeability of the Mycobacterium tuberculosis cell envelope [J].

Jackson, M ;

Raynaud, C ;

Lanéelle, MA ;

Guilhot, C ;

Laurent-Winter, C ;

Ensergueix, D ;

Gicquel, B ;

Daffé, M .

MOLECULAR MICROBIOLOGY, 1999, 31 (05) :1573-1587

[49]

Jankute M., 2014, Molecular Genetics of Mycobacteria, VSecond, P535

[50] Elucidation of a protein-protein interaction network involved in Corynebacterium glutamicum cell wall biosynthesis as determined by bacterial two-hybrid analysis [J].

Jankute, Monika ;

Byng, Charlotte V. ;

Alderwick, Luke J. ;

Besra, Gurdyal S. .

GLYCOCONJUGATE JOURNAL, 2014, 31 (6-7) :475-483

← 1 2 3 4 5 6 7 8 9 10 →