Assembly of the Mycobacterial Cell Wall

被引：251

作者：

Jankute, Monika ^{[1
]}

Cox, Jonathan A. G. ^{[1
]}

Harrison, James ^{[1
]}

Besra, Gurdyal S. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

来源：

ANNUAL REVIEW OF MICROBIOLOGY, VOL 69 | 2015年 / 69卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

arabinogalactan; biosynthesis; cell wall; lipoarabinomannan; mycolic acids; peptidoglycan; MYCOLIC ACIDS; CORYNEBACTERIUM-GLUTAMICUM; PHOSPHATIDYLINOSITOL MANNOSIDES; LIPOARABINOMANNAN BIOSYNTHESIS; STRUCTURAL FEATURES; ARABINAN BIOSYNTHESIS; NONREDUCING TERMINI; N-GLYCOLYLATION; LENGTH CONTROL; CROSS-LINKING;

D O I：

10.1146/annurev-micro-091014-104121

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mycobacterium tuberculosis remains one of the most successful bacterial pathogens, claiming over 1.3 million lives worldwide in 2013. The emergence of multidrug-resistant and extensively drug-resistant isolates has prompted the need for new drugs and drug targets. M. tuberculosis possesses an unusual cell wall dominated by lipids and carbohydrates that provides a permeability barrier against hydrophilic drugs and is crucial for its survival and virulence. This large macromolecular structure, termed the mycolylarabinogalactan-peptidoglycan complex, and the phosphatidyl-myo-inositol based lipoglycans are key features of the mvcobacterial cell wall. Assembly of these cell wall components is an attractive target for the development of chemotherapeutics against tuberculosis. Herein, we focus on recent biochemical and molecular insights into these complex molecules of M. tuberculosis cell wall.

引用

页码：405 / 423

页数：19

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