Modeling Immunity and Inflammation in Stroke Can Mice Be Trusted?

被引:9
作者
Dirnagl, Ulrich [1 ,2 ,3 ,4 ]
机构
[1] Univ Med Berlin, Charite, Ctr Stroke Res Berlin, Dept Neurol,ExcellenceCluster NeuroCure, Berlin, Germany
[2] Univ Med Berlin, Charite, Ctr Stroke Res Berlin, Dept Expt Neurol,ExcellenceCluster NeuroCure, Berlin, Germany
[3] German Ctr Neurodegenerat Dis DZNE, Berlin, Germany
[4] German Ctr Cardiovasc Dis DZHK, Berlin, Germany
关键词
immune system; inflammation; models; animal; stroke; INJURY; MOUSE;
D O I
10.1161/STROKEAHA.114.005640
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
引用
收藏
页码:E177 / E178
页数:2
相关论文
共 7 条
[1]   Found in Translation Preclinical Stroke Research Predicts Human Pathophysiology, Clinical Phenotypes, and Therapeutic Outcomes [J].
Dirnagl, Ulrich ;
Endres, Matthias .
STROKE, 2014, 45 (05) :1510-1518
[2]   The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury [J].
Enzmann, Gaby ;
Mysiorek, Caroline ;
Gorina, Roser ;
Cheng, Yu-Jung ;
Ghavampour, Sharang ;
Hannocks, Melanie-Jane ;
Prinz, Vincent ;
Dirnagl, Ulrich ;
Endres, Matthias ;
Prinz, Marco ;
Beschorner, Rudi ;
Harter, Patrick N. ;
Mittelbronn, Michel ;
Engelhardt, Britta ;
Sorokin, Lydia .
ACTA NEUROPATHOLOGICA, 2013, 125 (03) :395-412
[3]   Inflammatory findings on species extrapolations: humans are definitely no 70-kg mice [J].
Leist, Marcel ;
Hartung, Thomas .
ARCHIVES OF TOXICOLOGY, 2013, 87 (04) :563-567
[4]   Central nervous system injury-induced immune deficiency syndrome [J].
Meisel, C ;
Schwab, JM ;
Prass, K ;
Meisel, A ;
Dirnag, U .
NATURE REVIEWS NEUROSCIENCE, 2005, 6 (10) :775-786
[5]   Of mice and not men: Differences between mouse and human immunology [J].
Mestas, J ;
Hughes, CCW .
JOURNAL OF IMMUNOLOGY, 2004, 172 (05) :2731-2738
[6]   Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis [J].
Sena, Emily S. ;
Briscoe, Catherine L. ;
Howells, David W. ;
Donnan, Geoffrey A. ;
Sandercock, Peter A. G. ;
Macleod, Malcolm R. .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2010, 30 (12) :1905-1913
[7]   Genomic responses in mouse models poorly mimic human inflammatory diseases [J].
Seok, Junhee ;
Warren, H. Shaw ;
Cuenca, Alex G. ;
Mindrinos, Michael N. ;
Baker, Henry V. ;
Xu, Weihong ;
Richards, Daniel R. ;
McDonald-Smith, Grace P. ;
Gao, Hong ;
Hennessy, Laura ;
Finnerty, Celeste C. ;
Lopez, Cecilia M. ;
Honari, Shari ;
Moore, Ernest E. ;
Minei, Joseph P. ;
Cuschieri, Joseph ;
Bankey, Paul E. ;
Johnson, Jeffrey L. ;
Sperry, Jason ;
Nathens, Avery B. ;
Billiar, Timothy R. ;
West, Michael A. ;
Jeschke, Marc G. ;
Klein, Matthew B. ;
Gamelli, Richard L. ;
Gibran, Nicole S. ;
Brownstein, Bernard H. ;
Miller-Graziano, Carol ;
Calvano, Steve E. ;
Mason, Philip H. ;
Cobb, J. Perren ;
Rahme, Laurence G. ;
Lowry, Stephen F. ;
Maier, Ronald V. ;
Moldawer, Lyle L. ;
Herndon, David N. ;
Davis, Ronald W. ;
Xiao, Wenzhong ;
Tompkins, Ronald G. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (09) :3507-3512