Effects of maternal exposure to cadmium on pregnancy outcome and breast milk

被引:122
作者
Nishijo, M
Nakagawa, H
Honda, R
Tanebe, K
Saito, S
Teranishi, H
Tawara, K
机构
[1] Kanazawa Med Univ, Dept Publ Hlth, Uchinada, Ishikawa 9200293, Japan
[2] Kanazawa Med Univ, Dept Hyg, Uchinada, Ishikawa 9200293, Japan
[3] Toyama Med Pharmaceut Univ, Fac Med, Dept Obstet & Gynecol, Toyama, Japan
[4] Toyama Med Pharmaceut Univ, Fac Med, Dept Publ Hlth, Toyama, Japan
关键词
D O I
10.1136/oem.59.6.394
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Objective: The effects of cadmium (Cd) on birth weight have been discussed in the scientific literature. However, investigations on the effects of maternal body burden of Cd on the next generation during pregnancy and lactation have been limited. The relation between maternal exposure to Cd and pregnancy outcome or Cd in breast milk in Japanese mothers was investigated. Methods: Cd concentrations in urine and colostrum milk samples of 57 mothers were measured by atomic absorption spectrophotometery. The relations between maternal urinary Cd and infant growth, gestational age at birth, and Cd in breast milk were investigated. Results: The rate of perterm deliveries of mothers with higher urinary Cd (greater than or equal to2 nmol/mmol creatinine (Cr)) was higher than that of mothers with lower urinary Cd (<2 nmol/mmol Cr). The gestational age was significantly correlated with urinary Cd even after adjustment for maternal age. The height and weight of newborn infants of mothers with higher urinary Cd were significantly lower than those of the newborn infants of mothers with lower urinary Cd, but these decreases were ascribed to early delivery induced by Cd. The Cd in breast milk of mothers with higher urinary Cd was significantly higher than that of mothers with lower urinary Cd. A significant positive correlation was found between maternal urinary Cd and Cd in breast milk. Conclusion: Maternal exposure to Cd seems to increase early delivery, which leads to a lower birth weight. Also, the Cd is transferred in part to the next generation through breast milk after birth.
引用
收藏
页码:394 / 396
页数:3
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