A historical perspective of pancreatic cancer mouse models

被引：9
作者：
Colyin, Emily K. [1 ]
Scarlett, Christopher J. [2 ]
机构：
[1] Univ Sydney, Royal N Shore Hosp, Kolling Inst Med Res, Bill Walsh Translat Canc Res Lab, St Leonards, NSW 2065, Australia
[2] Univ Newcastle, Sch Environm & Life Sci, Pancreat Canc Res Nutr Food & Hlth Res Grp, Ourimbah, NSW, Australia
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2014年 / 27卷
关键词：
Pancreatic cancer; Mouse models; Genetically engineered mouse models; Patient-derived xenografts; TUMOR-SUPPRESSOR GENE; MULTIPLE ENDOCRINE NEOPLASIA; SUBRENAL CAPSULE XENOGRAFTS; MUCINOUS CYSTIC NEOPLASMS; T-ANTIGEN; INTRAEPITHELIAL NEOPLASIA; TRANSGENIC MICE; ACINAR-CELLS; SLEEPING-BEAUTY; DRUG RESPONSE;
D O I：
10.1016/j.semcdb.2014.03.025
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Pancreatic cancer is an inherently aggressive disease with an extremely poor prognosis and lack of effective treatments. Over the past few decades, much has been uncovered regarding the pathogenesis of pancreatic cancer and the underlying genetic alterations necessary for tumour initiation and progression. Much of what we know about pancreatic cancer has come from mouse models of this disease. This review focusses on the development of genetically engineered mouse models that phenotypically and genetically recapitulate human pancreatic cancer, as well as the increasing use of patient-derived xenografts for preclinical studies and the development of personalised medicine strategies. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：96 / 105
页数：10
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