Association Between the NFKB1-94ins/del ATTG Polymorphism and Cancer Risk: An Updated Meta-Analysis

被引：18

作者：

Duan, Wenyuan ^{[1
]}

Wang, Erli ^{[1
]}

Zhang, Fengquan ^{[1
]}

Wang, Tongjian ^{[1
]}

You, Xiangdong ^{[2
]}

Qiao, Bin ^{[1
]}

机构：

[1] Gen Hosp Jinan Mil Reg, Inst Cardiovasc Dis, Jinan 250022, Shandong, Peoples R China

[2] Shandong Ctr Dis Control & Prevent, Div Qual Management, Jinan, Shandong, Peoples R China

来源：

CANCER INVESTIGATION | 2014年 / 32卷 / 07期

关键词：

Cancer genetics; Carcinogenesis; Risk and prevention; NF-KAPPA-B; NFKB1 GENE INCREASES; FUNCTIONAL INSERTION/DELETION POLYMORPHISM; PROMOTER REGION; TRANSCRIPTION FACTOR; CELL CARCINOMA; ENVIRONMENT INTERACTIONS; COLORECTAL-CANCER; NO ASSOCIATION; SUSCEPTIBILITY;

D O I：

10.3109/07357907.2014.911881

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To assess the effect of the NFKB1 -94ins/del polymorphism on cancer, we conducted ameta-analysis based on 25 studies including 8,750 cases and 9,170 controls. Overall, the -94ins/del polymorphism was associated with cancer risk in the pooled analysis and in Asian population, whereas no association was observed in Caucasian population. Stratified analysis by subtypes of cancer showed that the -94ins/del polymorphism was associated with oral squamous cell carcinoma and ovarian cancer risk, but had no association with colorectal cancer, bladder cancer, and renal cell cancer. Our meta-analysis suggests the NFKB1 -94ins/del polymorphism affects cancer susceptibility, and the association is ethnic-specific.

引用

页码：311 / 320

页数：10

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