Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism

被引：704

作者：

He, Jin ^{[1
,2
]}

Zhang, Peiwen ^{[1
,2
]}

Shen, Linyuan ^{[1
,2
]}

Niu, Lili ^{[1
,2
]}

Tan, Ya ^{[1
,2
,3
]}

Chen, Lei ^{[1
,2
]}

Zhao, Ye ^{[1
,2
]}

Bai, Lin ^{[1
,2
]}

Hao, Xiaoxia ^{[1
,2
]}

Li, Xuewei ^{[1
,2
]}

Zhang, Shunhua ^{[1
,2
]}

Zhu, Li ^{[1
,2
]}

机构：

[1] Sichuan Agr Univ, Coll Anim Sci & Technol, Chengdu 611130, Peoples R China

[2] Sichuan Agr Univ, Farm Anim Genet Resource Explorat & Innovat Key L, Chengdu 611130, Peoples R China

[3] Guizhou Acad Agr Sci, Inst Anim Husb & Vet, Guiyang 550005, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 17期

基金：

中国国家自然科学基金;

关键词：

short-chain fatty acids; inflammation; glycose and lipid metabolism; signalling pathways; ACTIVATED PROTEIN-KINASE; NF-KAPPA-B; HUMAN LARGE-INTESTINE; DIET-INDUCED OBESITY; GUT MICROBIOTA; COUPLED RECEPTOR; SKELETAL-MUSCLE; HISTONE ACETYLATION; ADIPOSE-TISSUE; BLOOD-GLUCOSE;

D O I：

10.3390/ijms21176356

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Short-chain fatty acids (SCFAs), particularly acetate, propionate and butyrate, are mainly produced by anaerobic fermentation of gut microbes. SCFAs play an important role in regulating energy metabolism and energy supply, as well as maintaining the homeostasis of the intestinal environment. In recent years, many studies have shown that SCFAs demonstrate physiologically beneficial effects, and the signalling pathways related to SCFA production, absorption, metabolism, and intestinal effects have been discovered. Two major signalling pathways concerning SCFAs, G-protein-coupled receptors (GPRCs) and histone deacetylases (HDACs), are well recognized. In this review, we summarize the recent advances concerning the biological properties of SCFAs and the signalling pathways in inflammation and glucose and lipid metabolism.

引用

页码：1 / 16

页数：16

共 140 条

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