Atherosclerosis, biomarkers of atherosclerosis and Alzheimer's disease

被引：8

作者：

Fiolaki, Aidonio ^{[1
]}

Tsamis, Konstantinos I. ^{[1
]}

Milionis, Haralampos J. ^{[2
]}

Kyritsis, Athanassios P. ^{[1
]}

Kosmidou, Maria ^{[2
]}

Giannopoulos, Sotirios ^{[1
]}

机构：

[1] Univ Ioannina, Dept Neurol, Sch Med, Ioannina 45110, Greece

[2] Univ Ioannina, Dept Internal Med, Sch Med, Ioannina 45110, Greece

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2014年 / 124卷 / 01期

关键词：

Alzheimer's disease; dementia; inflammation; metabolic syndrome; cardiovascular risk factors; inflammation biomarkers; C-REACTIVE PROTEIN; APOLIPOPROTEIN-E POLYMORPHISM; TOTAL CHOLESTEROL LEVEL; VASCULAR RISK-FACTORS; AMYLOID BETA-PROTEIN; E EPSILON-4 ALLELE; CEREBROSPINAL-FLUID; METABOLIC SYNDROME; COGNITIVE FUNCTION; SERUM-CHOLESTEROL;

D O I：

10.3109/00207454.2013.821988

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) is the most prevalent type of dementia, involving progressive deterioration of neuronal networks. Although the pathophysiological mechanism of AD is not fully elucidated, apart from beta-amyloid and tau protein, a diverse number of factors such as cardiovascular risk factors, inflammation, and lipids metabolism may play a significant role. Numerous epidemiological and laboratory studies support vascular injury and inflammation, as key pathological processes. The present review is focused on cardiovascular risk factors, lipids, and circulating biomarkers of inflammation, discussing them as independent mechanisms converging to the same final pathogenetic cascade of AD.

引用

页码：1 / 11

页数：11

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