A thiourea-appended rhodamine chemodosimeter for mercury(II) and its bioimaging application

被引：14

作者：

Tantipanjaporn, Ajcharapan ^{[1
,2
,4
]}

Prabpai, Samran ^{[1
,2
,4
]}

Suksen, Kanoknetr ^{[3
]}

Kongsaeree, Palangpon ^{[1
,2
,4
]}

机构：

[1] Mahidol Univ, Dept Chem, Fac Sci, Bangkok 10400, Thailand

[2] Mahidol Univ, Fac Sci, Ctr Excellence Prot & Enzyme Technol, Bangkok 10400, Thailand

[3] Mahidol Univ, Dept Physiol, Fac Sci, Bangkok 10400, Thailand

[4] Mahidol Univ, Fac Sci, Ctr Excellence Innovat Chem, Bangkok 10400, Thailand

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2018年 / 192卷

关键词：

Hg2+-selective chemodosimeter; Fluorescence detection; Rhodamine; Thiourea; Bioimaging; FLUORESCENT OFF-ON; AQUEOUS-SOLUTION; LIVING CELLS; SENSOR; HG2+; CHEMOSENSOR; PROBE; ION;

D O I：

10.1016/j.saa.2017.10.057

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

A rhodamine-thiourea conjugate RTP with an o-phenylenediamine linker was developed as a fluorogenic chemodosimeter for Hg2+ detection. In the presence of Hg2+, a colorless solution of RTP turned pink with a maximum absorption band at 555 nm and with a 62-fold fluorescence enhancement at 578 nm (Phi = 0.34). RTP is highly selective to Hg2+ among other metal ions with a detection limit of 1.6 nM (0.3 ppb). A similar rhodamine analog with a flexible ethylenediamine spacer was less selective and less sensitive than RTP. Hg2+ induced cyclic guanylation to yield a benzimidazole moiety and a subsequent ring-opening of the spirolactam unit resulted in chromogenic and fluorogenic changes. The membrane-permeable RTP probe was successfully demonstrated in monitoring of Hg2+ in cultured HeLa cells. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：101 / 107

页数：7

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