A thiourea-appended rhodamine chemodosimeter for mercury(II) and its bioimaging application

被引：14
作者：
Tantipanjaporn, Ajcharapan [1 ,2 ,4 ]
Prabpai, Samran [1 ,2 ,4 ]
Suksen, Kanoknetr [3 ]
Kongsaeree, Palangpon [1 ,2 ,4 ]
机构：
[1] Mahidol Univ, Dept Chem, Fac Sci, Bangkok 10400, Thailand
[2] Mahidol Univ, Fac Sci, Ctr Excellence Prot & Enzyme Technol, Bangkok 10400, Thailand
[3] Mahidol Univ, Dept Physiol, Fac Sci, Bangkok 10400, Thailand
[4] Mahidol Univ, Fac Sci, Ctr Excellence Innovat Chem, Bangkok 10400, Thailand
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2018年 / 192卷
关键词：
Hg2+-selective chemodosimeter; Fluorescence detection; Rhodamine; Thiourea; Bioimaging; FLUORESCENT OFF-ON; AQUEOUS-SOLUTION; LIVING CELLS; SENSOR; HG2+; CHEMOSENSOR; PROBE; ION;
D O I：
10.1016/j.saa.2017.10.057
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
A rhodamine-thiourea conjugate RTP with an o-phenylenediamine linker was developed as a fluorogenic chemodosimeter for Hg2+ detection. In the presence of Hg2+, a colorless solution of RTP turned pink with a maximum absorption band at 555 nm and with a 62-fold fluorescence enhancement at 578 nm (Phi = 0.34). RTP is highly selective to Hg2+ among other metal ions with a detection limit of 1.6 nM (0.3 ppb). A similar rhodamine analog with a flexible ethylenediamine spacer was less selective and less sensitive than RTP. Hg2+ induced cyclic guanylation to yield a benzimidazole moiety and a subsequent ring-opening of the spirolactam unit resulted in chromogenic and fluorogenic changes. The membrane-permeable RTP probe was successfully demonstrated in monitoring of Hg2+ in cultured HeLa cells. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：101 / 107
页数：7
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