Inverse association of colorectal cancer prevalence to serum levels of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in a large Appalachian population

被引:33
作者
Innes, Kim E. [1 ,2 ]
Wimsatt, Jeffrey H. [3 ]
Frisbee, Stephanie [4 ]
Ducatman, Alan M. [3 ,5 ,6 ]
机构
[1] W Virginia Univ, Sch Publ Hlth, Dept Epidemiol, Morgantown, WV 26506 USA
[2] Univ Virginia Hlth Syst, Charlottesville, VA 22908 USA
[3] W Virginia Univ, Sch Med, Dept Med, Morgantown, WV 26506 USA
[4] W Virginia Univ, Sch Publ Hlth, Dept Hlth Policy Management & Leadership, Morgantown, WV 26506 USA
[5] W Virginia Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Morgantown, WV 26506 USA
[6] W Virginia Univ, Sch Med, Ctr Canc, Morgantown, WV 26506 USA
基金
美国国家卫生研究院;
关键词
Colorectal cancer epidemiology; Colon cancer; Perfluorooctanoate (PFOA); Perfluorooctane sulfonate (PFOS); Perfluorocarbons; Perfluoroalkyl acids; Peroxisome proliferator-activated receptors (PPARs); Gender; Body mass index; Inflammation; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PROLIFERATOR-ACTIVATED RECEPTORS; REPRODUCTIVE FACTORS; COLON-CANCER; METABOLIC SYNDROME; RISK-FACTORS; PPAR-GAMMA; ACID PFOA; STATINS; AGENTS;
D O I
10.1186/1471-2407-14-45
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are persistent environmental contaminants that affect metabolic regulation, inflammation, and other factors implicated in the development and progression of colorectal cancer (CRC). However, the link between these compounds and CRC remains unknown. In this cross-sectional study, we investigated the association of CRC diagnosis to PFOA and PFOS blood levels in a large Appalachian population. Methods: Participants were 47,359 adults >= 21 years of age and residing in six PFOA-contaminated water districts in the mid-Ohio Valley (N = 47,151 cancer-free adults, 208 cases of primary CRC). All participants completed a comprehensive health survey between 2005 and 2006; serum levels of PFOA, PFOS, and a range of other blood markers were also measured. Medical history was assessed via self report and cancer diagnosis confirmed via chart review. Results: CRC showed a strong inverse, dose-response association with PFOS serum levels (odds ratio (OR) adjusted for potential confounders = 0.2, 95% confidence interval (CI) 0.2,0.3) for highest vs. lowest quartile of PFOS, P-trend < 0.00001) and a significant, but more modest inverse association with PFOA (adjusted OR = 0.6 (CI 0.4, 0.9) for highest vs. lowest quartile, P-trend = 0.001). These inverse associations were stronger in those diagnosed within the previous 6 years and resident in the same water district for a minimum of 10-15 years preceding assessment. The relationship between PFOA and CRC was also more pronounced in men and leaner adults, and showed a stronger linear trend at lower exposure levels. Conclusions: In this large cross-sectional study, we found a strong, inverse association between PFOS and likelihood of CRC diagnosis and a significant, although more modest inverse association between PFOA and CRC. If confirmed in prospective investigations, these findings may aid in identifying new strategies for CRC prevention and treatment and inform future studies regarding mechanisms underlying CRC pathogenesis.
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页数:15
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共 72 条
  • [1] Rate of Decline in Serum PFOA Concentrations after Granular Activated Carbon Filtration at Two Public Water Systems in Ohio and West Virginia
    Bartell, Scott M.
    Calafat, Antonia M.
    Lyu, Christopher
    Kato, Kayoko
    Ryan, P. Barry
    Steenland, Kyle
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2010, 118 (02) : 222 - 228
  • [2] Statins and the risk of colorectal cancer: A meta-analysis of 18 studies involving more than 1.5 million patients
    Bonovas, Stefanos
    Filioussi, Kalitsa
    Flordellis, Christodoulos S.
    Sitaras, Nikolaos M.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (23) : 3462 - 3468
  • [3] Impact of perfluorooctanesulfonate and perfluorooctanoic acid on human peripheral leukocytes
    Brieger, Anne
    Bienefeld, Nicole
    Hasan, Rafah
    Goerlich, Roland
    Haase, Hajo
    [J]. TOXICOLOGY IN VITRO, 2011, 25 (04) : 960 - 968
  • [4] Polyfluoroalkyl chemicals in the US population: Data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000
    Calafat, Antonia M.
    Wong, Lee-Yang
    Kuklenyik, Zsuzsanna
    Reidy, John A.
    Needham, Larry L.
    [J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2007, 115 (11) : 1596 - 1602
  • [5] Clark RB, 2002, J LEUKOCYTE BIOL, V71, P388
  • [6] In vitro characterization of the immunotoxic potential of several perfluorinated compounds (PFCs)
    Corsini, Emanuela
    Sangiovanni, Enrico
    Avogadro, Anna
    Galbiati, Valentina
    Viviani, Barbara
    Marinovich, Marina
    Galli, Corrado L.
    Dell'Agli, Mario
    Germolec, Dori R.
    [J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 2012, 258 (02) : 248 - 255
  • [7] Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement
    Cuzick, Jack
    Otto, Florian
    Baron, John A.
    Brown, Powel H.
    Burn, John
    Greenwald, Peter
    Jankowski, Janusz
    La Vecchia, Carlo
    Meyskens, Frank
    Senn, Hans Joerg
    Thun, Michael
    [J]. LANCET ONCOLOGY, 2009, 10 (05) : 501 - 507
  • [8] DeWitt J, 2009, CRIT REV TOXICOL, V39, P76, DOI [10.1080/10408440802209804, 10.1080/10408440802209804 ]
  • [9] Subchronic effects of perfluorooctanesulfonate exposure on inflammation in adult male C57BL/6 mice
    Dong, Guang-Hui
    Zhang, Ying-Hua
    Zheng, Li
    Liang, Zai-Fu
    Jin, Yi-He
    He, Qin-Cheng
    [J]. ENVIRONMENTAL TOXICOLOGY, 2012, 27 (05) : 285 - 296
  • [10] The association of drinking water source and chlorination by-products with cancer incidence among postmenopausal women in Iowa: A prospective cohort study
    Doyle, TJ
    Zheng, W
    Cerhan, JR
    Hong, CP
    Sellers, TA
    Kushi, LH
    Folsom, AR
    [J]. AMERICAN JOURNAL OF PUBLIC HEALTH, 1997, 87 (07) : 1168 - 1176