LENGTHENING OUR PERSPECTIVE: MORPHOLOGICAL, CELLULAR, AND MOLECULAR RESPONSES TO ECCENTRIC EXERCISE

被引:240
作者
Hyldahl, Robert D. [1 ]
Hubal, Monica J. [2 ]
机构
[1] Brigham Young Univ, Dept Exercise Sci, Provo, UT 84003 USA
[2] Childrens Natl Med Ctr, Med Genet Res Ctr, Washington, DC 20010 USA
关键词
eccentric exercise; lengthening; muscle damage; repeated bout effect; skeletal muscle; soreness; INDUCED MUSCLE DAMAGE; HUMAN SKELETAL-MUSCLE; NERVE GROWTH-FACTOR; CREATINE-KINASE RESPONSE; CONTRACTION-INDUCED INJURY; CORONARY-ARTERY-DISEASE; REPEATED BOUTS; INCREASED SUSCEPTIBILITY; ULTRASTRUCTURAL-CHANGES; INTRACELLULAR CALCIUM;
D O I
10.1002/mus.24077
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The response of skeletal muscle to unaccustomed eccentric exercise has been studied widely, yet it is incompletely understood. This review is intended to provide an up-to-date overview of our understanding of how skeletal muscle responds to eccentric actions, with particular emphasis on the underlying molecular and cellular mechanisms of damage and recovery. This review begins by addressing the question of whether eccentric actions result in physical damage to muscle fibers and/or connective tissue. We next review the symptomatic manifestations of eccentric exercise (i.e., indirect damage markers, such as delayed onset muscle soreness), with emphasis on their relatively poorly understood molecular underpinnings. We then highlight factors that potentially modify the muscle damage response following eccentric exercise. Finally, we explore the utility of using eccentric training to improve muscle function in populations of healthy and aging individuals, as well as those living with neuromuscular disorders. Muscle Nerve49: 155-170, 2014
引用
收藏
页码:155 / 170
页数:16
相关论文
共 160 条
[1]  
ABBOTT BC, 1952, J PHYSIOL-LONDON, V117, P380, DOI 10.1113/jphysiol.1952.sp004755
[2]  
ABRAHAM WM, 1977, MED SCI SPORT EXER, V9, P11
[3]   Why stretched muscles hurt -: is there a role for half-sarcomere dynamics? [J].
Allen, David G. .
JOURNAL OF PHYSIOLOGY-LONDON, 2006, 573 (01) :4-4
[4]   Calcium and the damage pathways in muscular dystrophy [J].
Allen, David G. ;
Gervasio, Othon L. ;
Yeung, Ella W. ;
Whitehead, Nicholas P. .
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2010, 88 (02) :83-91
[5]   Mechanisms of stretch-induced muscle damage in normal and dystrophic muscle: role of ionic changes [J].
Allen, DG ;
Whitehead, NP ;
Yeung, EW .
JOURNAL OF PHYSIOLOGY-LONDON, 2005, 567 (03) :723-735
[6]  
ARMSTRONG RB, 1984, MED SCI SPORT EXER, V16, P529
[7]  
ARMSTRONG RB, 1990, MED SCI SPORT EXER, V22, P429
[8]  
ASMUSSEN E, 1956, Acta Rheumatol Scand, V2, P109
[9]   INTRACELLULAR CALCIUM AND FORCE IN SINGLE-MOUSE MUSCLE-FIBERS FOLLOWING REPEATED CONTRACTIONS WITH STRETCH [J].
BALNAVE, CD ;
ALLEN, DG .
JOURNAL OF PHYSIOLOGY-LONDON, 1995, 488 (01) :25-36
[10]   Distribution of sarcomere length and intracellular calcium in mouse skeletal muscle following stretch-induced injury [J].
Balnave, CD ;
Davey, DF ;
Allen, DG .
JOURNAL OF PHYSIOLOGY-LONDON, 1997, 502 (03) :649-659