Expression of dyskinetic movements and turning behaviour in subchronic L-DOPA 6-hydroxydopamine-treated rats is influenced by the testing environment

被引：27
作者：
Pinna, Annalisa
Pontis, Silvia
Morelli, Micaela
机构：
[1] Univ Cagliari, Dept Toxicol, I-09124 Cagliari, Italy
[2] Univ Cagliari, Ctr Excellence Neurobiol Dependence, I-09124 Cagliari, Italy
[3] CNR, Inst Neurosci, Sect Cagliari, Cagliari, Italy
来源：
BEHAVIOURAL BRAIN RESEARCH | 2006年 / 171卷 / 01期
关键词：
dyskinetic movements; turning; L-DOPA; environment; sensitisation; 6-OHDA lesion;
D O I：
10.1016/j.bbr.2006.03.021
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Sensitisation in contralateral turning behaviour and induction of abnormal involuntary movements (AIMs) after subchronic intermittent L-DOPA were compared for their predictive validity as model of parkinsonian dyskinetic movements. L-DOPA treatment produced sensitisation in turning behaviour in 6-hydroxydopamine-lesioned rats, when animals were evaluated in hemispherical bowls but not in cages. In contrast, sensitisation in AIMs was obtained both in hemispherical bowls and cages. Results provide evidence that the choice of the environment used in evaluation of AIMs and turning behaviour is of crucial importance. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：175 / 178
页数：4
相关论文
共 23 条
[1]   CONDITIONED ROTATIONAL BEHAVIOR IN RATS WITH UNILATERAL 6-HYDROXYDOPAMINE LESIONS OF THE SUBSTANTIA-NIGRA [J].
CAREY, RJ .
BRAIN RESEARCH, 1986, 365 (02) :379-382
[2]   Differential regulation of GAD67, enkephalin and dynorphin mRNAs by chronic-intermittent L-dopa and A2A receptor blockade plus L-dopa in dopamine-denervated rats [J].
Carta, AR ;
Pinna, A ;
Cauli, O ;
Morelli, M .
SYNAPSE, 2002, 44 (03) :166-174
[3]   L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA [J].
Cenci, MA ;
Lee, CS ;
Björklund, A .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1998, 10 (08) :2694-2706
[4]  
EINAT H, 1993, BEHAV PHARMACOL, V4, P399
[5]   Characterization of enhanced behavioral responses to L-DOPA following repeated administration in the 6-hydroxydopamine-lesioned rat model of Parkinson's disease [J].
Henry, B ;
Crossman, AR ;
Brotchie, JM .
EXPERIMENTAL NEUROLOGY, 1998, 151 (02) :334-342
[6]   Effect of repeated L-DOPA, bromocriptine, or lisuride administration on preproenkephalin-A and preproenkephalin-B mRNA levels in the striatum of the 6-hydroxydopamine-lesioned rat [J].
Henry, B ;
Crossman, AR ;
Brotchie, JM .
EXPERIMENTAL NEUROLOGY, 1999, 155 (02) :204-220
[7]  
KOPIN IJ, 1993, ANNU REV PHARMACOL, V33, P467
[8]   Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease [J].
Lundblad, M ;
Andersson, M ;
Winkler, C ;
Kirik, D ;
Wierup, N ;
Cenci, MA .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2002, 15 (01) :120-132
[9]  
MORELLI M, 1993, BEHAV PHARMACOL, V4, P389
[10]  
NUTT JG, 1990, NEUROLOGY, V40, P340
123